ID A0A3Q3CX31_HAPBU Unreviewed; 385 AA.
AC A0A3Q3CX31;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=G protein subunit alpha 12 {ECO:0000313|Ensembl:ENSHBUP00000032728.1};
GN Name=GNA12 {ECO:0000313|Ensembl:ENSHBUP00000032728.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000032728.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000032728.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(12) subfamily.
CC {ECO:0000256|ARBA:ARBA00010405}.
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DR RefSeq; XP_005929357.1; XM_005929295.2.
DR AlphaFoldDB; A0A3Q3CX31; -.
DR STRING; 8153.ENSHBUP00000032728; -.
DR Ensembl; ENSHBUT00000025907.1; ENSHBUP00000032728.1; ENSHBUG00000019222.1.
DR GeneID; 102289811; -.
DR CTD; 503589; -.
DR GeneTree; ENSGT00940000157636; -.
DR OMA; GISEHIF; -.
DR OrthoDB; 2897309at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:InterPro.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000469; Gprotein_alpha_12/13.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF130; GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA-12; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00440; GPROTEINA12.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 17..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 44645 MW; 8D1827837519A7C1 CRC64;
MSGVVRTLSR CLLPAEASRD PVGSKERSRE RDAAQEREAR RRSREIDAMI ARERRAIRRL
VKILLLGAGE SGKSTFLKQM RIINGQEFDQ KALLDFRDTI YENILKGMRV LVDARDKLGI
SWQSCENEKQ GMLVMSWEGR VGASGVEPSE FQLYVMALSA LWADAGIQEA YTRRSEFQLS
ESVKYFLDNL DRIGQLSYIP SKQDILFARK ATKGIVEHDF VIKKIPFKMV DVGGQRSQRQ
KWFQCFDGIT SILFMASSSE YDQVLMEDRR TNRLVESMNI FETIVNNKLF LNVSIILFLN
KTDLLVEKIR TADIRKNFPE FRGDPRRLED VQAFLVQLFS RKRRNRGKPL FHHFTTAVDT
ENIRFVFHAV KDTILQENLK DIMLQ
//
