ID A0A3Q3CXF9_HAPBU Unreviewed; 375 AA.
AC A0A3Q3CXF9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00016861};
DE EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
DE AltName: Full=Glutaminyl cyclase {ECO:0000256|ARBA:ARBA00033159};
DE AltName: Full=Glutaminyl-tRNA cyclotransferase {ECO:0000256|ARBA:ARBA00042699};
GN Name=QPCT {ECO:0000313|Ensembl:ENSHBUP00000032958.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000032958.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000032958.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC ChEBI:CHEBI:87215; EC=2.3.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000001};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC {ECO:0000256|ARBA:ARBA00006014}.
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DR RefSeq; XP_005922417.1; XM_005922355.2.
DR AlphaFoldDB; A0A3Q3CXF9; -.
DR STRING; 8153.ENSHBUP00000032958; -.
DR Ensembl; ENSHBUT00000026336.1; ENSHBUP00000032958.1; ENSHBUG00000019588.1.
DR GeneID; 102309701; -.
DR GeneTree; ENSGT00390000003107; -.
DR OMA; GIQDDHI; -.
DR OrthoDB; 3091175at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03880; M28_QC_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR037457; M28_QC.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF5; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 127..354
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 375 AA; 42052 MW; 38B24379FCF3F2B4 CRC64;
MCKGATTSVA DRSHAASTMS LFHTVAVCVT LIHYTNGIPW TEEKLYHTAV TLTQDEIRAA
LSHTDVEQMW QRDLRPLLVT RYPGSAGSQA VQDHIKTTLG SLGAQWDVTE DKFVSQTPYG
PLPFTSLIAT LNPSAKRRLV LACHYDSKYY PPQWHGREFQ GATDSAVPCA MMLELARALD
LDLKAHKSLN SNLTLQLLFF DGEEALFQWT ATDSLYGSRH LAQKMEATAH PPGAADTNQL
HGIDLFVLLD LIGAPSPRFG NQFPSTTAWL SRLQHIEKRL HSMSQLVDHP NSVQYFWPNH
HVGHVLDDHI PFLNRGVRVL HLIPSPFPSV WHTFDDNEQN LDRSTIENLN KILQVFVLEY
LSARPTVPSN PQNAP
//
