ID A0A3Q3CXQ8_HAPBU Unreviewed; 1869 AA.
AC A0A3Q3CXQ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dedicator of cytokinesis 1 {ECO:0000313|Ensembl:ENSHBUP00000033118.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000033118.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000033118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005919560.1; XM_005919498.1.
DR Ensembl; ENSHBUT00000026643.1; ENSHBUP00000033118.1; ENSHBUG00000020126.1.
DR GeneID; 102312690; -.
DR CTD; 1793; -.
DR GeneTree; ENSGT00940000154974; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08694; C2_Dock-A; 1.
DR CDD; cd12051; SH3_DOCK1_5_A; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR047025; DOCK1_5_SH3.
DR InterPro; IPR047026; DOCK1_C2.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF1; DEDICATOR OF CYTOKINESIS PROTEIN 1; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 424..608
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1204..1615
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1610..1714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1736..1869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 711..738
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1610..1626
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1631..1658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1673..1712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1755..1787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1857
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1869 AA; 215734 MW; E45053C20ED65996 CRC64;
MSRWVPTKKE KYGVAIYNYD ARGEEELSLQ IGDTVHILET YEDWYRGYRL RRKSKKGIFP
ACYIHLKEAT VEGSGQKETV IPTELPLVQE VTTTLREWAT IWRDLYVGDK REMFNCVRDM
IYDLIEWRSQ ILSGTLPQDE LSELKQKVTS KIDYGNKYLD LDLVVRDKDG NILDPELTST
ISLFRAHEAA SKQIEDRIQE EKSQKQNIDL TRQAKFASTP AFALFVTLKN VVCKIGEDAE
VLMSLYDPVE SKFISENYLV KWSSCGLVKD IDQLHNLRAV FTDLGSEDLK REKISFVCQI
VRVGRMELRD NNTKKLTSGL RRPFGVAVMD VTDIITGKMD DEDKQHFIPF QPVAGENDFL
QTVINKVITA KEVNHKGQGL WVTLKLLPGD IHQIRKDFPH LVDRSTAVAR KMGFPEIIMP
GDVRNDIYVT LVQGDFDKGS KTTPKNVEVT MSVYDEDGKK LENVIFPGAG DEGINEYKSV
IYYQVKQPRW FETIKVAIPI EDVNRSHLRF TFRHRSSQDS KDKSEKIFAL SFVKLMRYDG
TTLRDGEHDL IVYKAEVKKL EDSSLYLNLP STKLEMEEKG YSTTGKNTQT LGICTISKDS
FQISTLVCST KLTQNVDLLG LLKWRSNTSL LQQNLRQLMK VEGGEVVKFL QDTLDALFNI
MMENSDSDTF DTLVFDALVF IIGLIADRKF QHFNPVLETY IRKHFSATLA YTKLTKVLKN
YVDNADKLTE QLLKAMKALE YIFKFIVRSR VLFNQLYENK GEADFMESLR NLFTSFNDMM
NSNSENTGMV KGAALKYIPT IVNDVKLVFD PKELSKLFTE FILKVPVGRL VKQKLDCLID
IVHSDLFNHH DCREILLPLM TDQLKFHLEK REDLKACCQL LSDILEVLYR KDVGPTQWHV
QIIMEKLLRT VNRTIISMGR DSPHIGSFVA SMTGVLRQMD DYHYAHLIST FGKIRSDVVD
FLMETFIMFK DLIGKNVYPS DWIIMNMMQN KVFLRAISQY AAVLNKKFLD QTNFELQLWN
NYFHLAVAFL TQESLQLENF SSDKRAKIFH RYQDMRRQIG FEIRDMWYNL GPHKIKFIPE
MVGPILEMTL VPEIELRKAT IPIFFDMMQC EFHFTMHFQR FENEIITKLD HEVEGGRGDE
QYKVLFQKIL LEHCRKHKYL ARTGENFVTL VVRLLERLLD YRTIMHDENK ENRMSCTVNV
LNFYKEIDRE EMYIRYLYKL CDLHKECDNY TEAAYTLLLH AKLLKWSDEA CAAHLTQRDG
YQATTQGQLK DHLYQEIINY FDKGKMWEEA IILGKELAEQ YENEMFDFEQ LSASLRKQAQ
FYENIVKVIR PKPDYFAVGY YGTGFPSFLR NKMFIYRGKE YERREDFEAR LLTQFPNAEK
MKTTTPPSED TKSSSGQYIQ CFTVKPILDL PAKFQNKSVS EQILSFYTVN EVHKFQYSRP
VRKGEKDPDN EFANMWIERT TYSTAYKLPG ILRWFEVKSV STEEISPLEN AIETMQQTNE
KISSMVQRHL NDPNLPINPL SMLLNGIVDP AVMGGFTNYE KAFFNDKYIQ EHPEDLEKIE
KLKDLIAWQI PHLAEGVRIH GEKVTEALRP FHDRMEACFK QLREKVEKQY GVKSLPPADE
RRGPRPPSMV RSFTMPSSQR PLSVASVTSI SSDNAPSRPG SDGFALEPLL PKKLHTKSQD
KLDRDEPEKD RKEKKKEKRN SKHQEVFDKE MKTADISLQP AEAVILSETI SPLRPQRPRS
QVLNQIVGDR RLSVSPGPPT SSSSSSSQCP PPITPRSKVS YNLHAVSSLE LNGMGCSDKG
ETPPPLPLKS NTADYGNLLD NQDLTSPSTP PPPPPHQRQF PPPLPSKTPP PPPPKTTRKQ
ASIDSGIVQ
//
