ID A0A3Q3CXT0_HAPBU Unreviewed; 1253 AA.
AC A0A3Q3CXT0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A7 {ECO:0000313|Ensembl:ENSHBUP00000033153.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000033153.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000033153.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR RefSeq; XP_014190766.1; XM_014335280.1.
DR AlphaFoldDB; A0A3Q3CXT0; -.
DR Ensembl; ENSHBUT00000026717.1; ENSHBUP00000033153.1; ENSHBUG00000019916.1.
DR GeneID; 102290413; -.
DR GeneTree; ENSGT00940000157045; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF105; SODIUM BICARBONATE COTRANSPORTER 3; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 606..628
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 693..716
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 723..741
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 821..839
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 859..877
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 907..926
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 947..971
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1007..1026
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1033..1052
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1084..1115
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 142..280
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 378..528
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 577..1085
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..69
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1253 AA; 139802 MW; A6CC10882470C503 CRC64;
MDEQNEGEHV LTGLDEEAIV DHGKTSFATL SNHEKDDFES HRAVYVGVHV PLGRESKRRH
RHRGHKQRKK KNRDSEEGKE DGRDSPTYDT PSQRVQFILG TEDDDLEHVP HDLFTEMDEL
SFRDGTATEW RETARWLKFE EDVEDGGERW SKPYVATLSL HSLFELRSCI LNGTVLLDMR
ASSIEEIADM VIDSMVASGQ LKEDLRDKVR EAMLKKHHHQ NERKLSNRIP LVRSIADIGK
KHSDPLLLEK NGEGLSSSRL SLHKPGTASS VSNLSQRRES RVSVLLNHLL PSSSSNTGLF
PGPSPFTTPQ ALRRSQSPSH RQGVVLGPQG IPEVVVSPPE DEDPPEEEAV SPQLSRRASS
ASQSVELLPL EGPLVSQNSV PNNLDSNKAM DRRPSKVGVS RESSSVDFSK VDMNFMKKIP
PGAEASNVLV GEVDFLEKPI IAFVRLSPAV LITGLTEVPV PTRFLFLLLG PHGKGPQYHE
IGRSMATLMT DEIFHDVAYK AKDRTDLLSG IDEFLDQVTV LPPGEWDPTI RIEPPKNVPS
QIKRKIPLQP NGSAPPAGEL EKEEDHHAGP ELQRTGRIFG GLVLDVKRKA PFYWSDIRDA
LSLQCLASVL FLYCACMSPV ITFGGLLGEA TKGNISAIES LFGASLTGVA YSLFAGQPLT
ILGSTGPVLV FEKILFKFCK DYSLSYLSLR TSIGLWTAFL CILLVATDAS SLVCYITRFT
EEAFAALICV IFIYEALEKL FHLGELYPVN MHNSLDNLTL YSCQCSPPAN ATDEVMQKWN
QSGYSPDSIE WSSLSVSTCK LLHGDFVGPA CGHHGPYIPD VLFWSVILFF TTFFLSSFLK
QFKTERYFPT RVRSTISDFA VFITIMIMVL VDYLMGIPSP KLNVPDRFEP TSKNRGWLMD
PLGENPWWTL LVAVLPAMLC TILIFMDQQI TAVIINRKEH KLKKGCGYHL DLLLVAIMLG
VCSIMGLPWF VAATVLSISH VNSLKVESGC SAPGEQPKFL GIREQRVTGF MIFVLMGCSV
FMTSVLKFIP MPVLYGVFLY MGVSSLKGIQ FFDRIKLFGM PAKHQPDLIY LRYVPLWKVH
IFTLIQLSCL VLLWVIKVSA AAVVFPMMVL ALVFIRKLLD FFFTKRELSW LDDLMPESKK
KTEDDKKKKA REKLDEESGL EEEEEMGIKD TYEDSNRLKI PVKELSGSSD TDPLVVNISD
EMAKTAVWKA VNSSAESCVQ PVKLSGSQEK VACVRVDVSP DTPGRDSTTE TFL
//
