ID A0A3Q3CZ67_HAPBU Unreviewed; 845 AA.
AC A0A3Q3CZ67;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Extracellular calcium-sensing receptor-like {ECO:0000313|Ensembl:ENSHBUP00000034073.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034073.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000034073.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q3CZ67; -.
DR STRING; 8153.ENSHBUP00000034073; -.
DR Ensembl; ENSHBUT00000028501.1; ENSHBUP00000034073.1; ENSHBUG00000021396.1.
DR GeneTree; ENSGT01050000244874; -.
DR OMA; FLPVISH; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15283; 7tmC_V2R_pheromone; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061:SF528; C-FAMILY ODORANT RECEPTOR OLFCD2-RELATED; 1.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 575..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 690..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..758
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 576..840
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 845 AA; 94632 MW; 21536D6C2BBF6F14 CRC64;
MHPLILEMNW LGCNNLLRGD PENPLLSKNG DIILGGMFSF HTSWKERKDS YMNKPLPLQC
ASLNFRDLQF AQAMLFAIEE INKSTDLLPG ISLGYKIYDT CDNVARSVGV TLALANGNVS
VPSKTPCTTS AHVQAIIGAT SSSTTIVLAT VTGPFFLPVI SHLATCACLS DKTKYPSFLR
TIPSDYYQSR ALAHLVKHFG WTWVGAIRTN SDYGNNGMAT FTETAQQLGI CLEYSVFFFR
TDPSAKIQRI IEIIKASTSK VIVTFLSRPD LNVLLHEFLY HNLSGYQWVG TESWIFDSQT
AEMDIHHILD GAIGLSIPIA HVSGLRNFIL TEKPLNSSNT QLFTEFWETL FSCKFKELKS
SSDIQRECTG HEDMTGVQNS FIDMSLMPIF NNVYKGVYAV AHALHNILSC NKTCNKNVQL
DPFMILQHIR KSHFTTKEGD EVYFNENGDP AAKYDIINWQ PRENGIVEFV TVGLYDTSLA
VEKQLHLQSK ALIWAKNSKQ VPLSVCSEKC PPGTRKVLQK GRPVCCYDCI RCAEGEISNT
TDSVTCLRCL PEFWSNERRD ACIKKEAVFL SYEDIMGVLL TAASLFGACM TIGVILIFFK
YRKTPIVRAN NSELSFLLLF SLILCFLCSL TFIGQPSDWS CMLRHVAFGI TFVLCISCLL
GKTMVVLMAF RATRPGSNVQ KWFGQTQQRL CVTAFTLMQV IICITWLTTS PPFPFKNFKE
IKDKITLECA LGSAVGFWAV LGYIGLLAIL CFIFAFLARK LPDNFNEAKF ITFSMLIFCA
VWITFIPAYV SSPGKFSVAV EIFAILASSF GLLICIFIPK CYIILMKPEK NTKKRIMGKK
VPQSL
//
