ID A0A3Q3CZE9_HAPBU Unreviewed; 549 AA.
AC A0A3Q3CZE9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=BOS complex subunit NCLN {ECO:0000256|ARBA:ARBA00034873};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034248.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000034248.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR RefSeq; XP_005918698.1; XM_005918636.2.
DR AlphaFoldDB; A0A3Q3CZE9; -.
DR STRING; 8153.ENSHBUP00000034248; -.
DR Ensembl; ENSHBUT00000028851.1; ENSHBUP00000034248.1; ENSHBUG00000021732.1.
DR GeneID; 102303298; -.
DR GeneTree; ENSGT00500000044945; -.
DR OMA; GGCITAY; -.
DR OrthoDB; 458841at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd03882; M28_nicalin_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR016574; Nicalin.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR31826; NICALIN; 1.
DR PANTHER; PTHR31826:SF3; NICALIN-1-LIKE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR PIRSF; PIRSF011018; Nicalin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..549
FT /note="BOS complex subunit NCLN"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018542327"
FT TRANSMEM 509..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 200..325
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 549 AA; 61805 MW; 30415E751BFEAD50 CRC64;
MLQSTAAIAL LLCVQSLHGS ALPAVSSYEF TAYRMQQYNL GQHKYGCRGA IVVAEARSAE
EPSLTRRCVI MKVEDFTTEK YSEAQRQNAA AILILLPQNI SSIPHNAVES FMVSESETLL
KETLMPVYVA PEDEQLLCMY EEVKQAAATR TSSIFVRVLR SMVTATAFQI LVINNAPIKA
TTDNAIITLE GVLLGAVEDA PTIVIAAHYD SYGLAPWLSY GADSNAGGVT ILIELARLFQ
KLYSSPRTRP QFNLMFSLTG GGKYNFLGTK RWIEENLDHA ESSLLHDNVA FVLCLDTLAN
GDELYMHVSR PPKPDTPMQS FIQQLEEVVS SRFPWVKVGL VHKKINLVES TVAWEHERYS
LRRILGFTLS HLEDPKSELR GSMLDTMSKV DFRKLKRNGI IIAEALARYM YNLSDKGSPK
DVQVFKGQLD IQDSRISSLM SFLTSVPRAT QLLDKEPSHI LLVNSLEHEF KRYLQQVHRH
TFRQDKRDPD ITFFDQMSQP IVMYRVKPAA FDLFLGGCIA AYLGIVYYAI QNFGFLYTKL
KAAVKTKHH
//
