ID A0A3Q3D082_HAPBU Unreviewed; 734 AA.
AC A0A3Q3D082;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit alpha {ECO:0000256|ARBA:ARBA00021841};
DE EC=2.7.11.10 {ECO:0000256|ARBA:ARBA00012442};
DE AltName: Full=Nuclear factor NF-kappa-B inhibitor kinase alpha {ECO:0000256|ARBA:ARBA00032095};
GN Name=CHUK {ECO:0000313|Ensembl:ENSHBUP00000034733.1};
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034733.1, ECO:0000313|Proteomes:UP000264840};
RN [1] {ECO:0000313|Ensembl:ENSHBUP00000034733.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-
CC seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA-
CC COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC ChEBI:CHEBI:456216; EC=2.7.11.10;
CC Evidence={ECO:0000256|ARBA:ARBA00023939};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_005950212.1; XM_005950150.1.
DR AlphaFoldDB; A0A3Q3D082; -.
DR STRING; 8153.ENSHBUP00000034733; -.
DR Ensembl; ENSHBUT00000029807.1; ENSHBUP00000034733.1; ENSHBUG00000022539.1.
DR GeneID; 102311796; -.
DR GeneTree; ENSGT00950000182937; -.
DR OMA; MEHSVMD; -.
DR OrthoDB; 3949542at2759; -.
DR Proteomes; UP000264840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008384; F:IkappaB kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1270.250; -; 1.
DR Gene3D; 6.10.250.2110; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041185; IKBKB_SDD.
DR InterPro; IPR046375; IKBKB_SDD_sf.
DR InterPro; IPR022007; IKKbetaNEMObind.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR PANTHER; PTHR22969:SF13; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; 1.
DR Pfam; PF18397; IKBKB_SDD; 1.
DR Pfam; PF12179; IKKbetaNEMObind; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM01239; IKKbetaNEMObind; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 15..301
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 734 AA; 83766 MW; 3D3DC956E9B1D693 CRC64;
MERAALKQSQ PCGSWEMKER LGTGGFGHVY LYQHLESGEK IAVKLCRLEL NSKNKDRWTR
EIQIMKKLNH VNVVQARDVP AELSSIAIND LPLLAMEYCS KGDLRKVLNK PENCCGLKES
EVLALLSDIG SGIQYLHENK VIHRDLKPEN IVLQEIDGKH VHKIIDLGYA KDLDQGSLCT
SFVGTLQYLA PELFENKPYT VTVDYWSFGT VIFECTCGFR PFLHHMQPVQ WTSKVKNKGP
KDIMAVEDMN GEVRFSTHLP YPNNLSRPLL EPVESLLQML LLWDPAMRGG GLDPGANKPY
FYTALQNILN MKIIHVLDMT SAQLHSVVLG AEDSLHSLQL SLQTQTQSHI PPLSQELLLE
TGISLDPRRP LAHCLPDGLR GWDTFIVYLF DKSLTKYSGP LTARPLPDSV NFIVRETKTQ
LPLSALRKVW GEAVSYICGL KEDYNRLYQG QRAAMLSLLR FNTNLTRYKN MLFSQSQQLQ
AKLSFFKTSI QHDLEQYTKQ SKAGISSEKM LKKWHENEEK ADEFTKVADV GYLDEEIVAL
HSEIVELQRS PFARRQGDVM EQLEQKAIEL YKQLKAKCKT SDPPHGYSDS SDMVKTILQT
VQNQDRVLKD MYTHLSTILV CKQRIMDLFP KLEKALKNIT TAETVVMQMQ VSRQREFWYL
LKIACAQSSS PSPSLTQPST DSETVHHLLD ENQRYLSQLT SLLQDATQEM EHSIMDQDWS
WTQYGAMKVK PQTL
//