ID   A0A3Q3D082_HAPBU        Unreviewed;       734 AA.
AC   A0A3Q3D082;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Inhibitor of nuclear factor kappa-B kinase subunit alpha {ECO:0000256|ARBA:ARBA00021841};
DE            EC=2.7.11.10 {ECO:0000256|ARBA:ARBA00012442};
DE   AltName: Full=Nuclear factor NF-kappa-B inhibitor kinase alpha {ECO:0000256|ARBA:ARBA00032095};
GN   Name=CHUK {ECO:0000313|Ensembl:ENSHBUP00000034733.1};
OS   Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX   NCBI_TaxID=8153 {ECO:0000313|Ensembl:ENSHBUP00000034733.1, ECO:0000313|Proteomes:UP000264840};
RN   [1] {ECO:0000313|Ensembl:ENSHBUP00000034733.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-
CC         seryl-[I-kappa-B protein]; Xref=Rhea:RHEA:19073, Rhea:RHEA-
CC         COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.10;
CC         Evidence={ECO:0000256|ARBA:ARBA00023939};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_005950212.1; XM_005950150.1.
DR   AlphaFoldDB; A0A3Q3D082; -.
DR   STRING; 8153.ENSHBUP00000034733; -.
DR   Ensembl; ENSHBUT00000029807.1; ENSHBUP00000034733.1; ENSHBUG00000022539.1.
DR   GeneID; 102311796; -.
DR   GeneTree; ENSGT00950000182937; -.
DR   OMA; MEHSVMD; -.
DR   OrthoDB; 3949542at2759; -.
DR   Proteomes; UP000264840; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008384; F:IkappaB kinase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.1270.250; -; 1.
DR   Gene3D; 6.10.250.2110; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR041185; IKBKB_SDD.
DR   InterPro; IPR046375; IKBKB_SDD_sf.
DR   InterPro; IPR022007; IKKbetaNEMObind.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR22969; IKB KINASE; 1.
DR   PANTHER; PTHR22969:SF13; INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT ALPHA; 1.
DR   Pfam; PF18397; IKBKB_SDD; 1.
DR   Pfam; PF12179; IKKbetaNEMObind; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM01239; IKKbetaNEMObind; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264840};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          15..301
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         44
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   734 AA;  83766 MW;  3D3DC956E9B1D693 CRC64;
     MERAALKQSQ PCGSWEMKER LGTGGFGHVY LYQHLESGEK IAVKLCRLEL NSKNKDRWTR
     EIQIMKKLNH VNVVQARDVP AELSSIAIND LPLLAMEYCS KGDLRKVLNK PENCCGLKES
     EVLALLSDIG SGIQYLHENK VIHRDLKPEN IVLQEIDGKH VHKIIDLGYA KDLDQGSLCT
     SFVGTLQYLA PELFENKPYT VTVDYWSFGT VIFECTCGFR PFLHHMQPVQ WTSKVKNKGP
     KDIMAVEDMN GEVRFSTHLP YPNNLSRPLL EPVESLLQML LLWDPAMRGG GLDPGANKPY
     FYTALQNILN MKIIHVLDMT SAQLHSVVLG AEDSLHSLQL SLQTQTQSHI PPLSQELLLE
     TGISLDPRRP LAHCLPDGLR GWDTFIVYLF DKSLTKYSGP LTARPLPDSV NFIVRETKTQ
     LPLSALRKVW GEAVSYICGL KEDYNRLYQG QRAAMLSLLR FNTNLTRYKN MLFSQSQQLQ
     AKLSFFKTSI QHDLEQYTKQ SKAGISSEKM LKKWHENEEK ADEFTKVADV GYLDEEIVAL
     HSEIVELQRS PFARRQGDVM EQLEQKAIEL YKQLKAKCKT SDPPHGYSDS SDMVKTILQT
     VQNQDRVLKD MYTHLSTILV CKQRIMDLFP KLEKALKNIT TAETVVMQMQ VSRQREFWYL
     LKIACAQSSS PSPSLTQPST DSETVHHLLD ENQRYLSQLT SLLQDATQEM EHSIMDQDWS
     WTQYGAMKVK PQTL
//