ID A0A3Q3DZU6_9LABR Unreviewed; 715 AA.
AC A0A3Q3DZU6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Engulfment and cell motility protein 3-like {ECO:0000313|Ensembl:ENSLBEP00000000197.1};
GN Name=ELMO3 {ECO:0000313|Ensembl:ENSLBEP00000000197.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000000197.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000000197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR AlphaFoldDB; A0A3Q3DZU6; -.
DR STRING; 56723.ENSLBEP00000000197; -.
DR Ensembl; ENSLBET00000000202.1; ENSLBEP00000000197.1; ENSLBEG00000000163.1.
DR GeneTree; ENSGT00940000159455; -.
DR InParanoid; A0A3Q3DZU6; -.
DR OrthoDB; 4872856at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF16; ENGULFMENT AND CELL MOTILITY PROTEIN 3; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 307..477
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 715 AA; 81869 MW; 2584FFEAB542B2D1 CRC64;
MPQQKDIVKI AIQMPGAYPQ LIQLDQKKPL SAVIKEVCDG WNLPGPDNYA LQNADGVQTY
ITESNRLDIK NGCILRLTKA PGRCAEDLFK GIQSSDSGVR CDSLKELAST STDVTFAQEF
ISRDGHLLLV KIVEDSNESN VIMTHTLTGF MELMDHGIVS WENLSSVFIK KIASFVNAKP
TDASIQQVSL DILESMVLSS HSLFLQVKQE VTMERLIAHL QVTNQQIQTK AMALLMALLQ
TAGDSDRQDM FAFLSKKNLR QYIYKNIIHS SGAVQDEMAH YLYVLQSVTL NHLEPRMRTP
LDCYSQEQRD ILHGLRQAAF ETESENSLSH ERRRSLCAKE FKKLGFSNNS NPGQDLVRTP
PGLLALDTMF YFAARYPDAY SRFVLENSSR EDKHECPFAR SSIQLTLILC EILRIGEPPS
ETGSHYHPIF FSQDRLMEEL FCVCIQLLNK TWKEMRATQE DFDKVMQVVR EQITRTLSSK
PTSLELFKNK VNALNYSEIL KLRQTERLHQ EETLAPPVLE LKERLKPELL ELIRQQRLNR
LCQGTMFRKI SSRRRQDKLW YCRLSPNHKM LHYGDVEEDT ENPPIESLQE KIPVADIKGL
LTGKDCPHMK EHKGKQNKEV LDQAFSISYD VEEYSLNFIA PSRTDFCLWT DGLSVLLGRE
MSSESMRSEL EILLSMEIKL RLLDLENVPI PDSAPVIPKP PSNYNFCYDF SQTEQ
//
