ID A0A3Q3E165_9LABR Unreviewed; 590 AA.
AC A0A3Q3E165;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=sphingomyelin phosphodiesterase {ECO:0000256|ARBA:ARBA00012369};
DE EC=3.1.4.12 {ECO:0000256|ARBA:ARBA00012369};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000000797.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000000797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine = H(+)
CC + N-hexadecanoylsphing-4-enine + phosphocholine;
CC Xref=Rhea:RHEA:45644, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:72959, ChEBI:CHEBI:78646, ChEBI:CHEBI:295975;
CC Evidence={ECO:0000256|ARBA:ARBA00023739};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45645;
CC Evidence={ECO:0000256|ARBA:ARBA00023739};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) +
CC phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639,
CC ChEBI:CHEBI:295975; EC=3.1.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00023999};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254;
CC Evidence={ECO:0000256|ARBA:ARBA00023999};
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SIMILARITY: Belongs to the neutral sphingomyelinase family.
CC {ECO:0000256|ARBA:ARBA00006335}.
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DR AlphaFoldDB; A0A3Q3E165; -.
DR STRING; 56723.ENSLBEP00000000797; -.
DR Ensembl; ENSLBET00000000862.1; ENSLBEP00000000797.1; ENSLBEG00000000634.1.
DR GeneTree; ENSGT00400000022168; -.
DR InParanoid; A0A3Q3E165; -.
DR OrthoDB; 73222at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
DR GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0006687; P:glycosphingolipid metabolic process; IEA:Ensembl.
DR CDD; cd09078; nSMase; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR038772; Sph/SMPD2-like.
DR InterPro; IPR017766; Sphingomyelinase/PLipase_C.
DR PANTHER; PTHR16320:SF21; SPHINGOMYELIN PHOSPHODIESTERASE 5; 1.
DR PANTHER; PTHR16320; SPHINGOMYELINASE FAMILY MEMBER; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 265..544
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT REGION 179..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 65951 MW; CDBA6132C1420CFF CRC64;
MALQASPFPN GFVACLHDVG WALILPCFWF LDRLIALFKS TTLEKSQRVE QECYLHPLKV
FFGFILLFIL FLATAPFAFL GFLLWAPLQA CRRPFCYHRE IPSSPEREIH RGFELVGKAS
FGFATANLCL LPDGIARFNN LGHTQHRAAT IGQHIVHGVC RPHIRIFVDS PSSCGTLSPS
NSILPAGNSS TYGATDRQTQ PPVGNHPDST EGHVSIPKTN SHVVCDPCDD TKEPSTEPPS
TLFNSNQNSN QQGETGHRSA PRALLSQGLR QQDNPPWEVS SLFPANVDIL CLEEVFDKRA
AKKLTKALKP VFGHILYDVG VYACQPPCSC SSFKFFNSGL FVASRFPVLE AQYHWFPNAS
GEDALAAKGL LSAKVLIGKN RRQKKVVGFF NCTHLYAPEG EGEIRCEQLN MVTKWIGDFQ
AANRLPDEDV AFDVLCGDFN FDNCSPDDTL EQSHCLFEEY RDPCRAGPGK EKPWVIGTLL
EQPTLYEDDI NTPEKLQRTL EREELRKQYI SPPVPAKGLK MDYPEADQPW IGRRIDYILY
RESSISKNCR TEIEEVTFVT QLAGLTDHIP VGLRLNVTMD SDSAEEQGLK
//
