ID A0A3Q3E1U9_9LABR Unreviewed; 763 AA.
AC A0A3Q3E1U9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rho GTPase-activating protein 12-like {ECO:0000313|Ensembl:ENSLBEP00000001087.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000001087.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000001087.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q3E1U9; -.
DR STRING; 56723.ENSLBEP00000001087; -.
DR Ensembl; ENSLBET00000001165.1; ENSLBEP00000001087.1; ENSLBEG00000000828.1.
DR GeneTree; ENSGT00950000182860; -.
DR InParanoid; A0A3Q3E1U9; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12070; SH3_ARHGAP12; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035491; ARHGAP12_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF107; RHO GTPASE-ACTIVATING PROTEIN 12; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16618; SH3-WW_linker; 2.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 234..261
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 276..309
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 402..503
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 569..761
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 93..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 87607 MW; 651FF29A5ED9BB4E CRC64;
MAELPIAPGQ VYIEVDYDYE YKSKDRVIGI HQGECYMLVK KTNEDWWQVR KDEGTKAFYV
PAQYVREVRK ALMPPPKPFA LWVKPTNLDL GLHDRPPENL HRHESSNRRS PSAQTASSGH
FSPPSQRRDC NNQAAIKGGS LPRNRARSPD MVRRLLDVDS TQHCDSAGEE RRTNDSESGD
ELSSSSTEHL QTVSSSGHGR SESPVYTNLQ ELKITQTHQP PVPSGSPIHA LGDWETYKDQ
NGRHFYYNRS TQERTWKPPR SRDASFGSSR GEGHSTGESA EWLKHTDEQG RPYYYSADGS
RSEWELPKYN LSPPQPSGDT PKSRSLDRRQ VEPIVLTKWR HSAYVQDPND KFFFLTATFS
PFIPLRLSIK MMDVYMTRFC FFFLSFFSIQ PSEKCGVLNV TKITEQGKKV RKNWTSSWTV
LQGFTLLFAK GQGGGTSWFG GGQSKPEFTV DLRGGSVEWA SKDKSSKKHV LEVKTRYGTE
LLIQSENDSF VNDWYRALQE TISTHAWESD EAFEEDMPEF SGAEKNDKEK DHRDSKKGRG
VSLKTSTSMD GPDNKKTRHK LKKFLTRRPT LQAVRDKGYI KDQVFGCSLS DLCHRESVTV
PSFVRMCIDH WNLAVIQKLR FAVNHDEKVN LVDSKWEDIH VTTGALKMYF RELPEPLFTY
ALFHDFVSSI KLSEYKHRVQ SIKDLVRALP KPNHDTMQTL FKHLRRVIDH GEENRMTTQS
VAIVFGPTLL RPETETLNMA VHMVYQNQIV ELILLEYENI FGR
//
