ID A0A3Q3E292_9LABR Unreviewed; 544 AA.
AC A0A3Q3E292;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acid sensing ion channel subunit family member 4 {ECO:0000313|Ensembl:ENSLBEP00000001053.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000001053.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000001053.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homotrimer or heterotrimer with other ASIC proteins.
CC {ECO:0000256|ARBA:ARBA00038726}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC4 subfamily. {ECO:0000256|ARBA:ARBA00038140}.
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DR AlphaFoldDB; A0A3Q3E292; -.
DR STRING; 56723.ENSLBEP00000001053; -.
DR Ensembl; ENSLBET00000001131.1; ENSLBEP00000001053.1; ENSLBEG00000000829.1.
DR GeneTree; ENSGT00940000159052; -.
DR InParanoid; A0A3Q3E292; -.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR020903; ENaC_CS.
DR PANTHER; PTHR11690:SF13; ACID-SENSING ION CHANNEL 4; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU000679}.
FT REGION 499..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 544 AA; 61390 MW; AA97D6293401A52C CRC64;
MPIEFVCKIK FAEEDEKQKS KQDGDRESLI EESCTPKAKD LARFANSCSL HGINHIFVSG
RLGIRQTIWA LAFLTSLALF LYQAAKCAIS YLEHPHITAL NEEATPEMVF PAVTICNINR
FRFSALTDAD IYHLANLTGL PPKNKDGHKP TDLMYPAPDM QDIFNRTGHQ LEEMLMSCNF
SGQNCSVEDF SVVYTRYGKC YTFNGNKTTS RKTKQGGMGN GLEIMLDIQQ DEYLPIWRET
NETSLEAGIR VQIHSQDEPP YIHQLGFGVS PGFQTFVSCQ EQRLTYLPQP WGNCRSTGKE
KFPGYDTYSI SACRLLCETN EVIQVCNCRM VHMPGTADIC PPSKITCVDK ALAQLQKNSG
DACPCETPCN LTRYGKELSM VKIPSKGSAR YLSRKYDKSE DYIRDNFLVL DIFFEALNYE
TIEQKKAYDV AGLLGDIGGQ MGLFIGASIL TILEILDYIY EVIKQRLQRM LKPQKEEKNK
QQTSTVATVG LDEMKVKEPN DMTRSHPQGA YANTILPNHH HPPPHPHSHQ RHAGHHGVFE
DFAC
//
