ID   A0A3Q3E342_9LABR        Unreviewed;       552 AA.
AC   A0A3Q3E342;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Acid-sensing ion channel 1C {ECO:0000313|Ensembl:ENSLBEP00000001785.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000001785.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000001785.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3Q3E342; -.
DR   STRING; 56723.ENSLBEP00000001785; -.
DR   Ensembl; ENSLBET00000001900.1; ENSLBEP00000001785.1; ENSLBEG00000001420.1.
DR   GeneTree; ENSGT00940000164727; -.
DR   InParanoid; A0A3Q3E342; -.
DR   OrthoDB; 3415680at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF252; ACID-SENSING ION CHANNEL 1C; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        67..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          506..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..521
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   552 AA;  62919 MW;  08616D1E7A83A2A7 CRC64;
     MAEAPSTESV ALGPNKKSNA QETPLKNTKS KSLKPSWREL TVSFIMRTKV HGLKFIFSPD
     KSKPQRVIWI MAFFLCISLL GTWSLNRIHY LMSFPAVTKI YMVWAHNMSF PAVTICNKNV
     FRVSTLTRED LYHSGYWMDL MYPNHTVMEK SLSILRDSHK QGLLSLLDFN NYNPHPDYRI
     NTTEMMGRLG HQLEEMLLEC RFRGDICTHK NFSTIYTRYG KCYTFNSGLD GNPLLTTLKG
     GTGNGLEIML DIQQDEYLPV WGETDETSYE AGIKVQIHSQ DEPPFIDQLG FGVAPGFQTF
     VSCQQQLLQY LPPPWGDCKS TPIDSEFFST YSITACRIDC ETRYLLENCN CRMVHMPGTS
     TVCTPEQYKD CADPALDFLV EKDNDYCVCQ TPCNMTRYGK ELSMVKIPSK ASAKYLAKKF
     NKTEQYIGEN ILVLDIFFEA LNYEKIEQKK AYEIAGLLGD IGGQMGLFIG ASVLTILEIF
     DYLYEVFKDK VLGYFIRKKR PQRCQSDNLE FPENPTSPGV TPNHAPRAPV TPSGVTRTVS
     DSRRTCYLVT RL
//