ID A0A3Q3E9T1_9LABR Unreviewed; 288 AA.
AC A0A3Q3E9T1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Calcium-binding protein 8 {ECO:0000313|Ensembl:ENSLBEP00000004170.1};
GN Name=CALN1 {ECO:0000313|Ensembl:ENSLBEP00000004170.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000004170.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000004170.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with PI4KB. This binding competes with FREQ/NCS1
CC binding in a calcium-dependent manner. {ECO:0000256|ARBA:ARBA00038636}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004521};
CC Single-pass type IV membrane protein {ECO:0000256|ARBA:ARBA00004521}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Golgi
CC apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00037801}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00037801}.
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DR AlphaFoldDB; A0A3Q3E9T1; -.
DR STRING; 56723.ENSLBEP00000004170; -.
DR Ensembl; ENSLBET00000004385.1; ENSLBEP00000004170.1; ENSLBEG00000003204.1.
DR GeneTree; ENSGT00940000159212; -.
DR InParanoid; A0A3Q3E9T1; -.
DR OrthoDB; 3936962at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP7/8-like_CS.
DR PANTHER; PTHR46311:SF3; CALCIUM-BINDING PROTEIN 8; 1.
DR PANTHER; PTHR46311; CALCIUM-BINDING PROTEIN 8-RELATED; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS00303; S100_CABP; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 261..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..140
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 141..176
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 288 AA; 32707 MW; F116C420030AFE5A CRC64;
MEEEVTEPDP QMVEPTGIQP PGMHFEVNGD LPGNPCLRDG TEEVMESPTR EPDVLQYPAE
YSQSHQYGEK MPFHHVTAGL LYKGNYLSRS LSESDSDVLA SISVEELDEI REAFKVLDRD
GNGFISKQEL GMAMRSLGYM PSEVELAIIM QRLDMDGDGQ VDFNEFMTIL GPKLLSSETR
EGFLGSTIDT IFWQFDMQRI ELEELKHILF YAFRDHLTMK DIENIIINEE ESLKENSGNC
QTEFEGVHPS KKNRQTCVRK SLICAFAMAF IISVMLIAAN QMLRNGME
//
