ID   A0A3Q3EB99_9LABR        Unreviewed;       516 AA.
AC   A0A3Q3EB99;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000003341.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000003341.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC         deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC         ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC         Evidence={ECO:0000256|ARBA:ARBA00001432};
CC   -!- SIMILARITY: Belongs to the SAMHD1 family.
CC       {ECO:0000256|ARBA:ARBA00005776}.
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DR   AlphaFoldDB; A0A3Q3EB99; -.
DR   Ensembl; ENSLBET00000003513.1; ENSLBEP00000003341.1; ENSLBEG00000002471.1.
DR   GeneTree; ENSGT00390000013867; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.30.70.2760; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR   PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          85..232
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   516 AA;  60436 MW;  5621A55B14A43506 CRC64;
     MLMLYLPEPS DKLELVSMVY CFMHFIVLSF CLFVFCQVFN DPIHGSIELH PLLIKIIDTP
     QFQRLRFIKQ LGGVYFVYPG ASHNRFEHSI GVGYLAGKLA EALRSRQPEL NHDRDVLCVQ
     IAGLCHDLGH GPFSHLYDGL FLPNLCVSQH EKGSCDMLDH LLKENNLEPV MRQYGLEPED
     DIPFIKEMIA GPLQESEGQK WPYEGRPEEK SFLYEIVSNK KNGVDVDKFD YLARDSYYLG
     IKNNFDFHRF LQFARVCKVE DKDCKERKRE TICTRDKEED NMYDLFYIRH RLHKRAYQHR
     VNKVIEHMIA EAFLKADGHI EIEGSLGSAE SEGKRISTAF KDMEAYTKLT DNVFEEILKS
     SRPELQEARE ILQNIVSRKI YKFVGERKPK VPIEDWKVSL NNLKPEDFEI LVINMDYGMK
     DENPVEHMHF YSKKEPDVAK PMSPENIFSE QLIRVFCKKI DDDSVEAARQ HFEQWYRSTF
     ETASDPVYKH VNSEFAFLCP YVRFICFMLI CGVFYD
//