ID A0A3Q3ECL5_9LABR Unreviewed; 581 AA.
AC A0A3Q3ECL5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSLBEP00000005185.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000005185.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000005185.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3Q3ECL5; -.
DR Ensembl; ENSLBET00000005456.1; ENSLBEP00000005185.1; ENSLBEG00000004002.1.
DR GeneTree; ENSGT00940000164067; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR PANTHER; PTHR46096:SF3; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..581
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018713402"
FT DOMAIN 28..370
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 392..518
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 581 AA; 64855 MW; 6B4A6439F606C880 CRC64;
MCLLKTCIFA LLLLSLPQST NQSCIEGSPK QCLDAEVAPG TNLAGEGFDI TKMERKGAFV
IDMNKWKTRQ ECTLCTNTFL ENKLQKLPVA VVDWRAIQSC SSKVVSKLHR SSESLVSSST
SSVENNWQAN LDLKLGNKGA SLMLAGTDSK LADYSMEKTK NDKFSFTSQG MACEYYSYRV
SRSAKLHREF QKAVNDLPKI YSSEQKQQYY KLIDTFGTHY ITKVKLGGSV QTVTSIRQCQ
ASLQGLSLEE VSMCLDVEAS ASVKVATMAA QSKHCKSDIN KMENQKSFSS LYNDRFTEIK
GGHTTEPDLL FSADKDPSAY KEWLNTIPQN PDIISYSLDS LHELLPRNTP VRKNLRSAIS
HYILERGLWK NCSERCQAGI KSDARDSCVC QCHNDPAVNQ ECCPTRKGMA RIIITVQRAS
GLWGDHSTAT DGYVKVSFNG QMVRRSPVIQ NNNNPRWAMI VDLGAQDLSE GGKVRFEVWD
QDNNWDDDLL GQCEHALSAG VKEDLCTLQH GQLFFKWEIT CAPSLTGDSC MDYKPSPMSQ
SLQKMYVSRH SHPVPEAILL EKGVFVDNSS SHRNQSHSTD S
//
