ID   A0A3Q3ECQ8_9LABR        Unreviewed;       396 AA.
AC   A0A3Q3ECQ8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE            EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000005230.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000005230.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC         Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001062};
CC   -!- SIMILARITY: Belongs to the glutaminase family.
CC       {ECO:0000256|ARBA:ARBA00011076}.
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DR   AlphaFoldDB; A0A3Q3ECQ8; -.
DR   Ensembl; ENSLBET00000005501.1; ENSLBEP00000005230.1; ENSLBEG00000003973.1.
DR   GeneTree; ENSGT00390000010463; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.238.210; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR041541; Glutaminase_EF-hand.
DR   PANTHER; PTHR12544; GLUTAMINASE; 1.
DR   PANTHER; PTHR12544:SF26; GLUTAMINASE; 1.
DR   Pfam; PF17959; EF-hand_14; 1.
DR   Pfam; PF04960; Glutaminase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          149..227
FT                   /note="Glutaminase EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF17959"
FT   REGION          26..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  44271 MW;  A7BCC191CDE23042 CRC64;
     MESSQTQEAE DSPYLCFQRT PSLRRKWRKR YGGLDGNKLL EPNKDPDMKD DGETTDESQQ
     RSSDNTDSTP RPAPRSMIQN QTQSAFQTPV QKPVSLVSPG PAVVAVSASN GCLKPPLPQA
     VVQPEDRGFP PAQPWFSTQQ SPSKRRAAAD ILFDSFASDE RINVNQFFEA IWSSGLHRSD
     PRLRECFFHL RKLQDAEGSV DRNTFQRCVT GFVSLILKAL QGRFVIPDFS TFTEETQKLF
     SRCRQLSSVQ EKEKESMDST KWGVSICTVD GQRLSLGDWA GSLVLGEVSW PLVYGVVVEQ
     LGADLVHRYV GMDSYSRYDS PFTLTKTGIP HSPLTETGAI VTTSLLQLAG RLSAEEEEKY
     DSVSDTKTLI GFLKLPETDC LFVCLFIHLF VCVCRC
//