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Database: UniProt
Entry: A0A3Q3EE68_9LABR
LinkDB: A0A3Q3EE68_9LABR
Original site: A0A3Q3EE68_9LABR 
ID   A0A3Q3EE68_9LABR        Unreviewed;       701 AA.
AC   A0A3Q3EE68;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   Name=NCSTN {ECO:0000313|Ensembl:ENSLBEP00000005751.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000005751.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000005751.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
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DR   AlphaFoldDB; A0A3Q3EE68; -.
DR   STRING; 56723.ENSLBEP00000005751; -.
DR   Ensembl; ENSLBET00000006047.1; ENSLBEP00000005751.1; ENSLBEG00000004425.1.
DR   GeneTree; ENSGT00390000014633; -.
DR   InParanoid; A0A3Q3EE68; -.
DR   OrthoDB; 1330770at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   CDD; cd03881; M28_Nicastrin; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..701
FT                   /note="Nicastrin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018588468"
FT   TRANSMEM        662..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..213
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   701 AA;  78206 MW;  0FD8D47F8D1913AF CRC64;
     MELQSNKWMV NLLVCCFFIG VSCNSVEKKI YIHLNYTVPC VRLLNATHQI GCQSALSGDV
     GVLHVLESEE NLDWVLRTGR NPPYLVILEY PLFTRSVMMK LKNGSSRVAG VAVVAPNTNP
     PEGFSPHTSC PNENTGVYTD AYDPALAHCN MTVWNPLGNG LSYEEYDFPI FSLKDDDDTR
     VIRQCYLDHN RAVNGSTPQY PLCAMQLYSH MSAVTDTATC MRRNDLNFSI SPEMVCDPLG
     DYNVWASTRP FNNTVKGHKM WESVVIAAAR LDSRSFFFDI APGAESGVSG FVTLLAAAHA
     LKNVTQEAPP NRTILYTFFQ GETFDYIGSS RLVYDMQNNQ FTVDLDNVHS VVEVGQVGLR
     ADSKLWLHSD PVSRKNSSVN EEMMKLINNF QSAAAGGNVS VEEPGFSQPL PPSSFQRFLR
     ARPIPGVVIE DHRSAFTNRF YESMYDNAEY LNISYPSNLT AEEQLEFVTD TAKALTEVAT
     LVARALYMQA GGAESQLSSI KADPQIVTGM LYGFLVRSNN SWFQQIVPSD LMSHLADRPT
     NFYVGVHQQS SEPTLLVQYL LANLTGNTPN ITQNDCQNQR EDEKDTESKH MYTYMWVQGT
     APPNSTKREG FCVRSTVRLS KALSPAFDLR EFTSKEYSTW TESRWKTIKG RIFLVASHEL
     EMLTLGVGVG ILISSLLITY IVSSKADMLF SAGREPATAT Y
//
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