ID A0A3Q3EE68_9LABR Unreviewed; 701 AA.
AC A0A3Q3EE68;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN Name=NCSTN {ECO:0000313|Ensembl:ENSLBEP00000005751.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000005751.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000005751.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
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DR AlphaFoldDB; A0A3Q3EE68; -.
DR STRING; 56723.ENSLBEP00000005751; -.
DR Ensembl; ENSLBET00000006047.1; ENSLBEP00000005751.1; ENSLBEG00000004425.1.
DR GeneTree; ENSGT00390000014633; -.
DR InParanoid; A0A3Q3EE68; -.
DR OrthoDB; 1330770at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR CDD; cd03881; M28_Nicastrin; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..701
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018588468"
FT TRANSMEM 662..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..213
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 701 AA; 78206 MW; 0FD8D47F8D1913AF CRC64;
MELQSNKWMV NLLVCCFFIG VSCNSVEKKI YIHLNYTVPC VRLLNATHQI GCQSALSGDV
GVLHVLESEE NLDWVLRTGR NPPYLVILEY PLFTRSVMMK LKNGSSRVAG VAVVAPNTNP
PEGFSPHTSC PNENTGVYTD AYDPALAHCN MTVWNPLGNG LSYEEYDFPI FSLKDDDDTR
VIRQCYLDHN RAVNGSTPQY PLCAMQLYSH MSAVTDTATC MRRNDLNFSI SPEMVCDPLG
DYNVWASTRP FNNTVKGHKM WESVVIAAAR LDSRSFFFDI APGAESGVSG FVTLLAAAHA
LKNVTQEAPP NRTILYTFFQ GETFDYIGSS RLVYDMQNNQ FTVDLDNVHS VVEVGQVGLR
ADSKLWLHSD PVSRKNSSVN EEMMKLINNF QSAAAGGNVS VEEPGFSQPL PPSSFQRFLR
ARPIPGVVIE DHRSAFTNRF YESMYDNAEY LNISYPSNLT AEEQLEFVTD TAKALTEVAT
LVARALYMQA GGAESQLSSI KADPQIVTGM LYGFLVRSNN SWFQQIVPSD LMSHLADRPT
NFYVGVHQQS SEPTLLVQYL LANLTGNTPN ITQNDCQNQR EDEKDTESKH MYTYMWVQGT
APPNSTKREG FCVRSTVRLS KALSPAFDLR EFTSKEYSTW TESRWKTIKG RIFLVASHEL
EMLTLGVGVG ILISSLLITY IVSSKADMLF SAGREPATAT Y
//