ID A0A3Q3EEW2_9LABR Unreviewed; 1520 AA.
AC A0A3Q3EEW2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000005903.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000005903.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR STRING; 56723.ENSLBEP00000005903; -.
DR Ensembl; ENSLBET00000006204.1; ENSLBEP00000005903.1; ENSLBEG00000004491.1.
DR GeneTree; ENSGT00940000159568; -.
DR InParanoid; A0A3Q3EEW2; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR CDD; cd00371; HMA; 6.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 6.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR00003; copper ion binding protein; 4.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF29; COPPER-TRANSPORTING ATPASE 1; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 6.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 6.
DR PROSITE; PS50846; HMA_2; 6.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT TRANSMEM 677..696
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 727..749
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 770..791
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 797..819
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 962..989
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1009..1029
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1380..1402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1408..1428
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 8..74
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 177..243
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 286..352
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 400..466
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 511..577
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 587..653
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 1520 AA; 164445 MW; 7C2514E9F7F0E13A CRC64;
MTQRVNLCSV SLGVQGMTCG SCVQSIEQRI GSQPGVRQIK VSLEQKNATI IFDPSQQSPE
SLSEAIEDMG FESSLSETST ATPISSDTQL IPTLNLTPAA QQEALEKLSQ IQGVLDVRES
PAQMGLNVTF VPSLIPAQQL SEVVANIKPL DIATPNSHGL QNGPTLSPSH TSGAGVSLLK
LRIEGMTCHS CTTTIEGKIG KLNGVDKIKV VLETQEATVV YLPYLITVQT IIDQIAVAGF
KSFVKSKPRP LLLSPSEVER FVDSQKPTVS SSSDSSEETE IFIDTTLTML RVKGMHCRSC
VVNIQDNISM LPGVSSVEVC LEKEKASICY DPLMVTVNQL QQAIEALPPG NFKTQPWDSS
CPLSPVPTLS KPALSPLQPA GATKTTPAAL QTSFIQPLGS TVKIHIEGMT CNSCVQTIEG
MISKKKGVMS AQVSLADHQG IFEYDSLLIT PEELREAIED MGFDAFLPES NSLLPESNFL
HSKSTSLIPL KELDGDIHKE SPKEHNRDTN SKCFIQIGGM TCASCVANIE RNLKNEPGIS
SVLVALMASK AEVRYNPEVI DPGRIADCVK ELGFTASVME NYEGSDGNLE LVVRGMTCAS
CVHKIESSLM REKGIIYASV ALATNKAHIK YDSEVIGPRD TIKLIESLGF EATLVKRDRT
ASHLDHSKEI KQWRKSFLVS LFFCVPVMGM MTYMIIMDHQ MPSPHHHNMT AEDRNLYHST
MFLERQLLPG LSIMNLLSFL FCVPVQFIGG RYFYIQAYKA LKHKSANMDV LIVLATTIAF
TYSLVVLIVA MAEKAKVNPI TFFDTPPMLF VFISLGRWLE QIAKSKTSEA LSKLMSLQAT
EATVVTLSSD MSILSEEQVD VELVQRGDVV KVVPGGKFPV DGRVIEGHSM ADESLITGEA
MPVTKKPGSC VIAGSINQNG SLLVSATHVG MDTTLSQIVK LVEEAQTSKA PIQQYADKIS
GYFVPFIVGI SLLTLVAWTV IGFLDFSLVE KYFPGFDKSI SRTEAVIRFA FQASITVLCI
ACPCSLGLAT PTAVMVGTGV GAQNGILIKG GGPLEMAHKV QSVVFDKTGT ITYGAPNVIQ
VKIVVEGNKM PRSRLLAIMG TAENNSEHPL GAAITKYCKK ELGTEALGVC TDFQAVPGCG
IRCQVSNTET LLKQADSDSE DNNQRNSVLI QISDTRMSTT SHPLIMDPQP LSLIQTATYV
VLIGNREWMR RNCLQVSSDV DDAMIEHERR GRTAVLVAVD NMLCAMIAIA DTVKPEAELA
VQTLTHMGLE VVLMTGDNSK TARAIAAQVG IRKVFAEVLP SHKVAKVEQL QRQGKRVAMV
GDGVNDSPAL AMADVGIAIG TGTDVAIEAA DVVLIRNDLL DVVGSIHLSK KTVKRIRINF
VFALIYNLIG IPIAAGVFLP FGLVLQPWMG SAAMALSSVS VVLSSLLLKC YTKPTAEKLE
ASLGGNRRQG SLSDVSVHIG MGDVRRPSPK LSLLDRIVNY SRASMNSLRS DKHSLNSLVL
SDPDKHSLLV GEELCEEEAC
//
