ID   A0A3Q3EFG7_9LABR        Unreviewed;      1013 AA.
AC   A0A3Q3EFG7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Protocadherin 8 {ECO:0000313|Ensembl:ENSLBEP00000006108.1};
GN   Name=PCDH8 {ECO:0000313|Ensembl:ENSLBEP00000006108.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000006108.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000006108.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q3EFG7; -.
DR   STRING; 56723.ENSLBEP00000006108; -.
DR   Ensembl; ENSLBET00000006409.1; ENSLBEP00000006108.1; ENSLBEG00000004693.1.
DR   GeneTree; ENSGT00940000155219; -.
DR   InParanoid; A0A3Q3EFG7; -.
DR   OrthoDB; 4259465at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 6.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF46; PROTOCADHERIN-8; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 6.
DR   SUPFAM; SSF49313; Cadherin-like; 5.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..1013
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018705755"
FT   TRANSMEM        698..721
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          35..135
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          136..244
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          245..352
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          367..463
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          464..573
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          579..672
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   REGION          728..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          853..887
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          922..952
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..749
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        859..882
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        927..944
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1013 AA;  109561 MW;  A080080A712C22F2 CRC64;
     MGGKGWNGRL VLVCVSLASL AAVTQAKTVK YQTFEEDAPG TVIGNLAKDI SSSASSSGGS
     RNNFRMMKQF NSSFIRLRES DGQLSIGERI DRERICKHIL HCLIAFDVVS FSKEQFKLIH
     VEVEVKDIND NSPEFPRKES SMEISENTAV GTRIPLDFAV DDDVGVNYIQ SYQISVNSHF
     SIDVLSRADG VKYAELVLMK ELDRETQASY ALELVAMDGG NPSRTGTTRI NIKVKDYNDN
     SPVFDRNSFS VDLPEDAPVG SLLLDLNAED PDEGPNGEVV YGFGNQVPTE IRQLFKVDRK
     TGRLTLESPI DFESKNTYEF DVQATDLGPN PSPAICKIVV QVQDVNDNAP EISITPMTSI
     TAGIAYITEA AARESFVALV STSDRDSGAN GQVHCTLYGH DHFRLQQAYE DSFMIVSTSP
     LDREKIPEYN LTVVAEDLGS PPFRTITQYT IRLTDENDNA PVFSKPVYEV AVVENNAPGA
     YITTVVARDM DLGSNGKVSY KLSDTYFMGS PISTFVSVDP ASGSLYALRS FNYEVVKQLE
     LRITASDGGS PPLSGSASVY VRVVDQNDNA PVITQPPLNN GSAEVLLPRD APSGYVITRV
     EARDADEGVN SELSYGLATG EPSVFSVNKV TGEIYLNQVL SHDVDETLSV TVTVSDNGRP
     ALTSTATLHF LIIAGSPPSD RTVYQAGSGD ETHAQWDLSV VIIVVLAGSC TLLLLAIILI
     ATTCNRRKRD KSGEDSDSYG EKGTLERGRN HVGDNPLLPL HAAGAGEAGG FDGHSYSSQA
     GGFTSAHPGG IDMCSASEDG SEVPCVYDSD SNSKLRGNKH EGYSTLPGYG NGKEAVRPIT
     IWKGNSYTTI SARDPAFSGK DSGKGDSDFN DSDSDVSADT HLKKDGVVVP PMGGQNALWA
     CTSECKVLGH SDRCWSPSAV RANAAPSPAP TLSSFSSLSK TASLPRDPNR RDNYYQAHIP
     KTVGLQSVYE KVLHREYDYV LVTPPRPVRV QEISEVTLPV YTPTPTHCPN DEE
//