ID A0A3Q3EGT1_9LABR Unreviewed; 773 AA.
AC A0A3Q3EGT1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=TLE family member 3, transcriptional corepressor {ECO:0000313|Ensembl:ENSLBEP00000005276.1};
GN Name=TLE3 {ECO:0000313|Ensembl:ENSLBEP00000005276.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000005276.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000005276.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR AlphaFoldDB; A0A3Q3EGT1; -.
DR Ensembl; ENSLBET00000005549.1; ENSLBEP00000005276.1; ENSLBEG00000003967.1.
DR GeneTree; ENSGT01030000234519; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF24; TRANSDUCIN-LIKE ENHANCER PROTEIN 3; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 18..143
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 573..614
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 615..656
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 137..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..60
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 151..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 83541 MW; 8553DD32252DFE72 CRC64;
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH
YVMYYEMSYG LNIEMHKQTE IAKRLNAILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN
AIIGVRGLPN LPLTQQQLQA QHLSHAAHGP PVQLPPHPSG LQPPGIPPVT GAGSGLLALG
ALGSQAHLPV KDEKNHHDLE HRERESSTNN SVSPSDSLRA ASEKHRGSSD YSLDSKKRKV
DDKDSMSRYD SDGDKSDDLV VDVSNEDPAT PRVSPAHSPP ENGLDKSRVL KKDAAPNSPA
SVASSGSTPS SKAKDHAHND KSSTPSLKSN TPTPRNEAPT PGTSTTPGLR PLTMGKPPGM
EALAAPALRT PLSIAGSYAS PFAMMGHHEM NGSLTSPGVY PGLISPQISA AAAAAYGRSP
IAGFDPHPHM RAPGLPASLT SISGGKPAYS FHVSADGQMQ PVPFPPDALI GPGIPRHARQ
INTLSHGEVV CAVTISNPTR HVYTGGKGCV KIWDISQPGS KSPVSQLDCL NRDNYIRSCK
LLPDGRTLIV GGEASTLTIW DLASQTPRIK AELTSSAPAC YALAISPDAK VCFSCCSDGN
IAVWDLHNQT LVRQFQGHTD GASCIDISHD GTKLWTGGLD NTVRSWDLRE GRQLQQHDFT
SQIFSLGYCP TGEWLAVGME SSNVEVLHHT KPDKYQLHLH ESCVLSLKFA YCGKWFVSTG
KDNLLNAWRT PYGASIFQSK ESSSVLSCDI SADDKYIVTG SGDKKATVYE VIY
//