ID   A0A3Q3EJF4_KRYMA        Unreviewed;       488 AA.
AC   A0A3Q3EJF4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Prostaglandin E2 receptor EP4 subtype-like {ECO:0000313|Ensembl:ENSKMAP00000002087.1};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000002087.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000002087.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q3EJF4; -.
DR   STRING; 37003.ENSKMAP00000002087; -.
DR   Ensembl; ENSKMAT00000002135.1; ENSKMAP00000002087.1; ENSKMAG00000001613.1.
DR   GeneTree; ENSGT01050000244902; -.
DR   OMA; YDTARVN; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004957; F:prostaglandin E receptor activity; IEA:InterPro.
DR   CDD; cd15142; 7tmA_PGE2_EP4; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001758; Prost_EP4_rcpt.
DR   InterPro; IPR008365; Prostanoid_rcpt.
DR   PANTHER; PTHR11866; G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER; 1.
DR   PANTHER; PTHR11866:SF32; PROSTAGLANDIN E RECEPTOR 4 (SUBTYPE EP4) C; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01788; PROSTANOIDR.
DR   PRINTS; PR00586; PRSTNOIDEP4R.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        49..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        82..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        121..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        277..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          62..338
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   488 AA;  54454 MW;  AFA341C602F396C1 CRC64;
     LRFFLSFFSH PVVDLTLKLA LGVSEKLDPN ALSHNHSSFP ALRLESRNLV TSATMFAVGV
     LGNLIAIVVL CVSKKEQKET TFYTLVCGMA ITDLLGTCFT SPVVIATYVS NRWPGGTLLC
     HFFSFSMLFF GSAGMSILCA MAVERYLAIN HAYFYSKHID RTMARFALLV TYLANIVLCI
     MPSFGFGQHV KHFPGTWCFL DWRALDPLGA CYSFLYGGVM LLLIAVTVLC NLAVCRSLVG
     MNQRTGIVRT ELCEQSGSRR RFPRLHSVTS AAEVQMFWLL VFMTIVFLVC SIPLVVRIFV
     NQLHDPSYIS AGGKPDYRSD ILAIRFASFN PILDPWVYIL CRKNLLLKGC GRLKRAVAWA
     KEGRGDDKGW VGGQNSPPSL HSSDTIYASL RRASYRNHMR HPLKTASFTD FAMRQAWEYD
     TSRANFHPFS VESTAIIGCD EEEEEAAARR EEAEKSSPGR SCVAHVRRVD IVTCTFSTPS
     SSQSVKCL
//