ID A0A3Q3EMP8_9LABR Unreviewed; 1081 AA.
AC A0A3Q3EMP8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A10 {ECO:0000313|Ensembl:ENSLBEP00000007347.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000007347.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000007347.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q3EMP8; -.
DR STRING; 56723.ENSLBEP00000007347; -.
DR Ensembl; ENSLBET00000007727.1; ENSLBEP00000007347.1; ENSLBEG00000005646.1.
DR GeneTree; ENSGT00940000156972; -.
DR InParanoid; A0A3Q3EMP8; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF32; SODIUM-DRIVEN CHLORIDE BICARBONATE EXCHANGER; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 493..515
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 527..550
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 570..592
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 599..621
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 708..726
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 746..764
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 794..813
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 834..858
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 966..983
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 990..1006
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 163..416
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 464..972
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..92
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1081 AA; 121834 MW; 2B6C3A62DCBE8460 CRC64;
MDTTDQSAQI EPLLLPTVNS PFGSSSGRGS LRNDDEAVVD RGGTRSQQGT NLEQEDVEGH
RTLYIGVHVP LGSTRHRSHR RHRHHGNKLK KRSRDRALTL VEGRESPVYD TPSQRVQFLL
GTEDDDMEHI PHDLFTEMDE ICARDGEDSE WRESARWLKF EEDVEDGGER WSKPYVATLS
LHSLFELRSC IINSTVLLDM RANCIEEIAD MVLDQQELYS PLGEELRKKV RETLLKRHHH
QNQKKLANRL PIVRSFADMG RRSSDLHLDK NGQLTSSQSH LDGKGDISRE NSSVDFSKID
LHFMKKIPPG AEACNVLVGE LEFLTKPVVA FVRLSPAVLL SGVAEVPITT RFLFILLGPL
GRGLQYHEIG RSIATLMTDE VFHDVAYKAK DRNDLIAGID EFLDQVTVLP PGEWDPSIRI
EPPKNVPSQE KRKKSNILPN GMVEGEEEDE DSGHGGPELQ RTGRWFGGLF LDIKRKAPHY
LSDYTDAFSL QCVASFLFLY CACMSPVITF GGLLGEATEG RISAIESLFG ASLTGIAYSL
FAGQPLTILG STGPVLVFEK ILFKFCKEYG LSYLSLRTCI GLWTAFLCIL LVATDASSLV
CYITRFTEEA FASLICIIFI YEALEKLMHL GEHYPFNKNN NLDKLTTYSC SCVEPSDPGN
GTLKYWEINN VTASEIYWEA LEVKDCIEKR GEFVGSACGP HGPYVPDVLF WCVILFFSTV
FMSAFLKEFK FSNYFPTKVR SIISDFAVFF TILTMVLVDY ALGIPSPKLQ VPSVFKPTRD
DRGWFINPLG PNPWWTAVIT VFPALLCTIL IFMDQQITAV IINRKEHKLK KGCGYHLDLF
MVGLMLGVCS LMGLPWFVAA TVLSISHVNS LKLESECSAP GEQPKFLGIR EQRFTGLMIF
MLMGCSVFMT SVLKFIPMPV LYGVFLYMGA SSLRGIQFFD RLTLFGMPGK HQPDFVYLRH
VPLRKVHLFT IIQLTCLILL WVIKTSKAAI VFPMMVLALV FIRKLMDCFF TKRELSWLDD
LMPESKKKKL EDADEEEEQS ILAEDEAVVQ VPLEGYKGIP VINITDEMSK GSFGNTWNEN
S
//
