ID A0A3Q3EP10_9LABR Unreviewed; 933 AA.
AC A0A3Q3EP10;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Cadherin-4 {ECO:0000256|ARBA:ARBA00041040};
GN Name=CDH4 {ECO:0000313|Ensembl:ENSLBEP00000009029.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000009029.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000009029.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q3EP10; -.
DR STRING; 56723.ENSLBEP00000009029; -.
DR Ensembl; ENSLBET00000009518.1; ENSLBEP00000009029.1; ENSLBEG00000006989.1.
DR GeneTree; ENSGT00940000158073; -.
DR InParanoid; A0A3Q3EP10; -.
DR OrthoDB; 5306553at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF81; CADHERIN-4; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR01820; DESMOCOLLIN.
DR SMART; SM00112; CA; 5.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..933
FT /note="Cadherin-4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018586933"
FT TRANSMEM 752..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 184..291
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 292..406
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 407..521
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 522..630
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 629..740
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 131..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 933 AA; 102422 MW; 5F658C598E7710B5 CRC64;
MRSDFALVLT AALLCDTVWR NNGEHLSKGP CRAGFSQSFY SVLISRDVLQ GQGIQKDTIV
SSQKVKFDDC MGNQAVVFQS SDPNFSVRTD GSIFAQGEGA SLDEPVQFKL TASGPHTQVW
GTVVQLAVID PPSPPQNENE VTNEEGKIAE RKERKDAFQE PPPVIMFSGS PVNDSKGLRR
QKRDWVIPPI NVAENSRGPF PQMLVSIRSD QDQDISIRYS ITGVGADQPP NEVFNIDPVV
GKMFVTKPLD REHRSSYHLR AHAVDMNGNQ VENPIDLYIF VIDMNDNRPE FKNQVYNGSV
DEGSKPGTYV MHLAAFDADD NTTANGMVRY RILSQTPHSP IPNMFTINSE TGDIVTVAPG
LDREKVSQYT IIVQATDMEG NLNFGLSNTA TAIITVSDIN DNPPMLTSRT FSGEVPENRV
DVVVANLTVI DADQPHSPNW NAIYRILSGD PTGHFTIRTD PVSNDGMVTV VKPVDFEMNR
AFMLTVVVSN QAHLASGIQS SLQSTAGVTI SVQDVNEPPY FPTNPKNIRF EEGVPAGTSL
TTFSASDPDR LQMQQTIRYS KLNDPADWLS INRTNGQIIT TGMLDRESVY VKNNIYEATF
LATDNGSPAA SGTGTLQIYL IDINDNPPAL IPKESQICER VNRNVNGVNI TAADADTDPN
AGPFVFELPS FPSSIRRNWT ISRISGDYAR LGLRYQIYLE PGVYEVPITV SDSGNPPLSN
RSVIKVKVCP CDENGDCTTL GAVAAAGLGT GAIISILICI IILLSLVLLF VVWIKRREKE
RQTKQLLIDP EDDVRDNILK YDEEGGGEED QDYDLSQLQQ PDSLEHIISK PPGVRRVDER
PIIPESQYPI RPVVPHPGDI GDFIHEGLRA ADNDPTAPPY DSLLVFDYEG SGSTAGSVSS
LNSSSTGDQD YDYLNDWGPR FKKLADMYGG GDD
//
