ID A0A3Q3ERF7_9LABR Unreviewed; 594 AA.
AC A0A3Q3ERF7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA topoisomerase 1 {ECO:0000256|ARBA:ARBA00019632};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=DNA topoisomerase I {ECO:0000256|ARBA:ARBA00033297};
GN Name=TOP1 {ECO:0000313|Ensembl:ENSLBEP00000008807.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000008807.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000008807.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR AlphaFoldDB; A0A3Q3ERF7; -.
DR STRING; 56723.ENSLBEP00000008807; -.
DR Ensembl; ENSLBET00000009278.1; ENSLBEP00000008807.1; ENSLBEG00000006737.1.
DR GeneTree; ENSGT00940000155006; -.
DR InParanoid; A0A3Q3ERF7; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd03488; Topoisomer_IB_N_htopoI_like; 1.
DR Gene3D; 1.10.132.10; -; 1.
DR Gene3D; 2.170.11.10; DNA Topoisomerase I, domain 2; 1.
DR Gene3D; 1.10.10.41; Yeast DNA topoisomerase - domain 1; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013034; DNA_topo_DNA_db_N_dom1.
DR InterPro; IPR013030; DNA_topo_DNA_db_N_dom2.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR018521; TopoI_AS.
DR InterPro; IPR025834; TopoI_C_dom.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR014727; TopoI_cat_a/b-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR InterPro; IPR008336; TopoI_DNA-bd_euk.
DR InterPro; IPR036202; TopoI_DNA-bd_euk_N_sf.
DR InterPro; IPR013499; TopoI_euk.
DR InterPro; IPR048045; Topoisomer_I_DNA-bd.
DR PANTHER; PTHR10290:SF5; DNA TOPOISOMERASE 1; 1.
DR PANTHER; PTHR10290; DNA TOPOISOMERASE I; 1.
DR Pfam; PF14370; Topo_C_assoc; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR Pfam; PF02919; Topoisom_I_N; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SMART; SM00435; TOPEUc; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF46596; Eukaryotic DNA topoisomerase I, dispensable insert domain; 1.
DR SUPFAM; SSF56741; Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment; 1.
DR PROSITE; PS00176; TOPOISOMERASE_I_EUK; 1.
PE 3: Inferred from homology;
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 193..566
FT /note="DNA topoisomerase I eukaryotic-type"
FT /evidence="ECO:0000259|SMART:SM00435"
FT COILED 143..170
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 473..540
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 594 AA; 70344 MW; DC7ACA496C1DABB9 CRC64;
VMMLMSCTST MISPVTLRRR YHVFSFPSLV YILLLLIRWE EERSTDGSKW RFLEHKGPVF
APPYEPLPDK VKFYYDGKLM KLSAPAEEVA TFFGKMLDHE YTTKDIFRKN FFKDWRKEMT
SEEKSKITDL NKCNFSDMNE YFKTQSEARK QMSKQEKQKI KEENERLLQE YGFCIMDNHK
ERIGNFRIEP PGLFRGRGDH PKMGMLKRRI RPEDIIINCS KDSKHPKPPQ GTKWKEVRHD
NKVTWLASWT ENIQGSIKYI MLNPSSRIKG EKDWQKYETA RRLKKCVDRI RNQYREDWKS
KEMRIRQRAV ALYFIDKLAL RAGNEKEEGE TADTVGCCSL RVEHIKLYPK MDDQEYVVEF
DFLGKDSIRY YNKIPVEKRV FKNLQLFLEN KQPEDDLFDR LNVRMTSMMD KLVTYFHISV
TKNYLSHLVV SFLGDAADDS IPAKILSYNR ANRAVAILCN HQRAPPKTFE KSMQNLQTKI
DEKQNQLSTA KKQLKAAKAD HKASHDEKSK KTLEVKRKAV QRIEEQLMKL QVQATDREEN
KQIALGTSKL NYLDPRISVA WCKKWSVPIE KIYNKTQREK FAWAIDMAEK DYEF
//
