ID A0A3Q3ERV1_KRYMA Unreviewed; 1130 AA.
AC A0A3Q3ERV1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 2 {ECO:0000313|Ensembl:ENSKMAP00000004492.1};
GN Name=SORCS2 {ECO:0000313|Ensembl:ENSKMAP00000004492.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000004492.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000004492.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q3ERV1; -.
DR STRING; 37003.ENSKMAP00000004492; -.
DR Ensembl; ENSKMAT00000004577.1; ENSKMAP00000004492.1; ENSKMAG00000003327.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF9; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2; 1.
DR Pfam; PF18911; PKD_4; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 2.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1130
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018541854"
FT TRANSMEM 1036..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 763..833
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 23..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1130 AA; 125858 MW; 3F173AAB95A8DF0B CRC64;
MAARVHLCLL LLTAAPLPGP AGCDSRALSR RGGQDGTFDL GGGGRGEGVG VGGGGGGGEG
SPMPGSHADD EGAVAPGGAP RVRRATSWDK QMSLLSSSFV LKGDATHNQA MVHWTGENSS
VILILTKYYH ADSTKVLESS LWRSTDYGTT YSKLNLMPGT TIVVTSFFIC PTNKKKVVMV
GSSINERDQM LFISTDEGSS FQRQSIDFTP ETLIFHPKEE DKLLAFCKDG RLYASADLGH
KWTLLQERVT KDRVFWSVSG VDVDPDLVHM EMQDTSGGYL YVTCLIQNCS DKMVTAQFLG
KIDHNSLVVQ DDYIFVKVTT GNRTKHYVSY QRNEFVLMRF PKYALPKDVQ IVSTDENQVF
LALQEWYQSD TYNLYQSDPQ GVYYSLILEN VRSTKQPEEN VLIDILEVRG VKGVFLANQK
IDGKVTTLIT YNKGRDWEPL APPTTDMNGK PVSCKVPDCH LHLHLRWADN PYVSGTVHTK
ESAPGLIMGA GNLGSKLVEY KEEMYITSDC GKTWRQVFEE EHHILYLDHG GVIVAIKDTS
IPLKILKFST DEGRTWNIHN FTSTSVFVDG LLSEPGDETL VMTVFGHISY RSDWELVKVD
FRQSFLRQCT ESDYESWQLT DLKGEKCIMG QERTFRKRKE TSFCIKGKSY TSALTSKPCQ
CTERDFNCDY GFERSHTEGD RCFADFWYDL DSPPEDCHLG RNYESSTGYR KVISNTCEGG
VNKQQSAKQH SCPLLAPKGL QVGIKGQMLA VAPGDDITFI VHQEQGDTSS TKYQVDLGDG
VRAIYQNLTV TDEPIQHRYE HPGVYKVTVK AENVAGHDEA TMYIQVTAPL QEVHLEVVPI
AKRNDEVNLT AVVLPTEANL TVFYWWIGGS FQPTLTLRNS ILTRFSQTGE VSVTVQVSNG
RSMVQDTKIV RVYDNFQILP LGFSRTLDHF NPNIPEWRDD LGQVVTKILA KITGVPQESL
VTVVKPGLPT TADLYVLPLD NKPTKRSKFV DKRIPAIVQA FNDNNVNFMV RGGLRVLVML
ADPNAGYHGA VGGPGIWALA VIFLISVIAT GSFILYKFKR KLPGNRNIYA QMHNEKEQEM
TSPVNHSEDT QHIIQGEEFI DDDLDSQTLG NAGGSPAFCS LIRTTTNHCY
//