ID A0A3Q3ES07_KRYMA Unreviewed; 4040 AA.
AC A0A3Q3ES07;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protocadherin Fat 3-like {ECO:0000313|Ensembl:ENSKMAP00000004547.1};
GN Name=FAT3 {ECO:0000313|Ensembl:ENSKMAP00000004547.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000004547.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000004547.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSKMAT00000004632.1; ENSKMAP00000004547.1; ENSKMAG00000001877.1.
DR GeneTree; ENSGT00940000154981; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 30.
DR CDD; cd00053; EGF; 1.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 32.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24025:SF23; CADHERIN-4; 1.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR Pfam; PF00028; Cadherin; 23.
DR Pfam; PF00008; EGF; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 30.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00232; CADHERIN_1; 13.
DR PROSITE; PS50268; CADHERIN_2; 29.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..4040
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018705758"
FT DOMAIN 42..156
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 157..264
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 374..469
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 470..575
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 584..677
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 723..827
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 828..932
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 933..1041
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1049..1146
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1147..1253
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1254..1360
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1362..1456
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1457..1562
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1563..1665
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1666..1726
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1755..1865
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1966..2067
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2068..2166
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2167..2267
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2268..2374
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2375..2476
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2477..2580
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2581..2794
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2795..2896
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2897..3001
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3002..3103
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3186..3290
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3291..3395
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3404..3507
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3737..3883
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3886..3923
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3925..3961
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 3985..4040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4023..4040
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3913..3922
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4040 AA; 446208 MW; 57A59B59E57BEA6B CRC64;
MLLLPSFSPF LNVILYIFLH FSSTQAQFLP TPRAGRALLL FTQPVYNASI FENSAARTYI
RSEVKMGVTL VPSWPLDVKY SIESGDSEGI FQADEFEMGD FCFLRICING GSGATLNREV
QDNYTLTVKA SAHEGLEALA TIYIKVLDTN DLRPLFSPTF YSFVVSESAP LGTSIGRVTA
TDADIGSNGE FYYFFKNRIE LFAVHPTSGV ISLTGQARID KKERFELEVQ VVDRGMKLYG
NNGISSTARL VLTVERVNEF APVLSAVAVV PSWTDKDLVY AIVTVEDKDE GLSGDIEWLS
IIEGDPYEQF VIERSAVGNE YRVKTLEEIN LDTYPYGCNL TFQAKDRGIP PKFSNTQVVQ
LVVTKRDSVL AKFENDVYVV KLSEIAPPGT IVEVVKISPA PLSVNYSFGS LSDPMHFDIN
PLTGVIMTTR QLTKISQDFI EIEVVDRISQ QRARVQITIE DANDNSPVFS QPSYQTAINE
SLPIGTVILV VSAVDVDKGE NGYVTHTING EKSLPFSIDQ NTGELRITRD LDFESSEDFY
TFAVRASDWG SPYRRESEVN ITIRVININD NRPAFEKISC RGMISRDFPI NKTIVTLSAI
DMDELGMVRY KILSGNELDN FNLHPDSGAL VLKRSFEAES LKSGIFNLKV VATDGELFSN
PIFVNVSVVR SRIPPSGLTC KETRVAQLLA ERMVSKASAM ARPRSTERYI DLFSTNRQAP
QFEALPTSIL VREDLTAGAS VFQVRARDSD VGFNGRVLFS IYDGNKENSF NINMESGLIT
VLQPLDRERV DRYFLNITIY DQGIPQMSNW RLLTVIIEDA NDNNPQFYQD DYSVIVSEEA
DIGMEVITIT AFDKDMGQNG QLYFIMQTSI PQFGIDSETG IVFVASQLDR ETYPVFSLMI
EVRDKAEKGT RRSSVTTLNI ILEDINDCSP VFMPSSYSTR VPEDLPPGAV ITWVQAQDPD
VGPGGQVRYF LFNDFNGTFE VGYINAVTGV LRIRKELDFE TKQFFNLTVF AEDRGVPSLQ
NQTFVEIEVA DVNENLYAPY FPDFAVRGSV KENSRAGTSV LTVSAKDDDK GRDGVLRYSV
HRGSGLGTFT IDEDTGVIYT AGTLDCETKN SYWLTVYATD RGAVPMSASV EVFIEVEDVN
DNAPLTSDPI YHPVIMENSP KDVSVICIQA QDPDLTATPS RLSYRISAGN PQNFFSINPK
TGLIATTARK LDREQQAEHF LEVTVIDGPV TTRQSTVWVI VHIEDENDNP PTFPEVTYRI
SLPERDRNKR GEPLYRVFAY DRDFGANANI TYSIIDGNKD EKFSIDPRTA MVSSKKMVTA
GSYDILTIKA EDSGNPPLWS TVKLHVKWIR KPVPSQVPLL FTQRSYNFSI SETTAVAQPV
GVVAVSQSST PVWFSIVGSF DMQFDLQVGV GTLVVAKPLD AEVQSVYNMT VQVTDGTNFA
TVFIRVQDSN DNPPVFSQPA YDISVSEDAP ADMELLRLRA SDMDERARLS FSIYGSVDPT
SMRLFRVNPG TGVVYSTDRL DYEARMQHIL TIMVKDQEFP FNRDLARILV AVEDTNDNIP
YFTSSIYDAI AYETFPVGTS VLQVTALDKD NGINASLFLH PGNTGGVFAI DNATGLIFTA
KHLDLTSLGF YTLTLRATDS GFPPLMATAS VRISLILSDF SKPKFSQKEY QAEIMENSEI
GTHLITVSAL SRSPLIYDII RGNEEHRFFI NHHTGVITTR KLLDFEVSLL TTNNNNSMDR
FKECVLLFQC FPLLLFHRYV GRVSEAAPVN SVVLGEDGNP LVIRATDKDR NHNALLVFQI
IDETARMFFS VDSGTGTIDS LDYETFSEFF FRVHVRDSGN PPKSADSPAE VIIKVININD
SPPKFSQDIY ETVLLLPTYM GVEVLRVEAS DPDLATDENQ SISPQLAYSL VDSNLEYFTV
EHSQISAVYN TNTVICVFKV WDGRFSSIAS ITVLVREAID SGLRFTLPVY SASIPENIPN
VTFVAVVNTV GHRLNDPLKY TLLNPGGRFS IRPTCGVVLT TGVPFDREEK GSYELVVEVS
REDEILRVAR VTVQVQVEDV NDNTPEFVNL PYYAVVQVES DPGSVIFMMS AVDKDYGLNG
VLSYSLKTRH RNFEVNSFVS AALNLNYICL HFKYKLVLVA TDSGSPRLSS EVELPVTVVN
KAMPVFDKPF YGVTVREDLA VSTSVLCMNA SSPEGQDIIF TITEGDSYFQ FDIGFDTGVI
KVIYPLDYEM RQYYRLTVKA TDTLTGAKSE VDVDIVILDV NDNPPLFQNT SYSAVLSENA
MIGTSVLQVF AQDQDSERNA AVTYQILSDI YNSTDYFQID SNRGLVFTAR MLDYELMQRH
NFIVRATDSG DPALSSDVSV TVVVTDTNDN PPNFSQTLYE AFVSDLAPRG HFVTCLQASD
ADICDFQRLR YSLLSGNEKM TFMMESDTGV LRLSNKRRQG MKLSYQLNVS VSDGVFTNTA
QVIVRVLGAN LYSPVFSQRF YLAEVLENSL PGSKVIQVSA TDEDSGLNGQ ITYSFINDLA
KTQFNIDADG LITTVQRLDR ENPLNKDMVL TVMALDGGGR ASFCTVRVVL ADENDNSPQF
RAVEYRMSIK ANVAKGSLVT QIQATDPDAG SNGRITYSLY SEARLSLVDV LEVEPDSGWM
MTKSTVDHLQ GTVLSFFVKA TDCGSPPKHS LVSAFIHVVP PDSLVPSFSQ PQYSFTIPED
TAVGMVLGSV YMGPGQTGFF TAVAGETLDS NQQGTFQVER DTGLIRLLKP LDYEEASSFR
FKVAATTRKD LIETVSTVDL EVKILDVNDN KPAFETNTYV ATVMEGMPAG TRVVQVRALD
PDWGSNGQVC GSNLHSIFAI DSKTGWITTV GSMDHEACSG YSFEVVAFDL AESQALSSTT
VVTVTVSDVN DNPPRFEREF YRGAVKESDP LGEVVAVLRT KDRDGADHNR LVSFYITGGN
QRGVFGLTLV QGEWKVYVSG LLDREQQDWY LLNITASDGL YVAHTAVEVT VMDANDNSPI
CNQAVYTASF PEDIPINKDI LTVGATDADS GSSAEIQYSL FGIGVEDFYM DANTGELRTA
TVMDRETTPA YKLIAQATDG GGLFCRSDIS LKVLDVNDNA PSFSSTHYLA SVYENAAPKA
LLTRLQADDP DEGRNIVCKN KYVTDNFRDS YRVHKRFAIV KDSSMFLQVD LTVLVLDVND
NAPVFQRRDY AVTVPEDVAV GTEVLRVLAT SADIGLNAEI TYNFRSGNEL GKFTVDRKLG
SISVADDLDF EVCKDFYITV EAWDSGSPPL STATMVIIEL MDVNDNAPVF DQGIYNVLIS
EDASVGQTVT RVFAEDLDSQ VNGRITYSIL KGDRSNHFWI DPVTGVLKVN KRLDRELVSR
YSLSVQAFDS GSPAMSSTVA VNVDISDVND NPPDFSPPNS TALNQAAGTT LLKLSVSDKD
SARNGPPFVF RIVSGNEGSF FSLDQTGTLK SNRVFGPEAS DSGIPSLTSS SWVFLRVLGN
SQYKPTVSPL EIFIVMLTDT FPGGPIGRIL ATDRDPNDVL SFTQRPEPKS MFEINRQDGS
IVALPGLEPG RYQMNATVSD GRFAVIADVS VQVEQVTDVL LRSALTLRFS SLSWEDLLSR
YLNQIRLTLR ALSGWKWSPG QQDPFHILSV QPVADTSHID LVLAMERPET SGGRRMEGFY
SQQELLAKLE EAGARGQMRG LLAGAALVSS TCSGALDCGD RVCENALVME GGLPVTYSTE
RISLVLPSFR RKETSGQTSL SFSGNSYIKY RVTESGQSGE MKLSLRIRTL QRQGVIMFTR
VNSFHLKYPF CFLFQIEGGR LWFQPINDGL WHSVSLELTR NYTLLSLDDS YSSPGPEEKK
GGAQDGFQGC LGSLALNGNE LPLQNKRSHY AEIAGLSEVK LGCVLYLDPC ISQPCLNGAA
CSSLPSGGFM CSCSSGFTGG RCETELTSCM PNPCQNGGDC KPVGSAFFCG CPGGLTGLMR
DNRHRSPCLC HHFPPHPLHR LQEKNQVQKG VGSRSGHCGC DGQHGRPTSG HGASYGPLRP
PGSPRKPEHE ERRGRQDHFQ
//
