ID A0A3Q3EWV8_9LABR Unreviewed; 813 AA.
AC A0A3Q3EWV8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=G-protein coupled receptor family C group 6 member A {ECO:0000256|ARBA:ARBA00039774};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000010837.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000010837.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q3EWV8; -.
DR STRING; 56723.ENSLBEP00000010837; -.
DR Ensembl; ENSLBET00000011416.1; ENSLBEP00000010837.1; ENSLBEG00000008387.1.
DR GeneTree; ENSGT00940000158416; -.
DR InParanoid; A0A3Q3EWV8; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016595; F:glutamate binding; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF5; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..813
FT /note="G-protein coupled receptor family C group 6 member
FT A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018598917"
FT TRANSMEM 567..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 568..796
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 813 AA; 90205 MW; 92CC849CEB8A3E07 CRC64;
MARHALLTCL HISLFLFMRV SADGTQVESA TAPGDFIIGG IFPLHEDVDR QNVTFEPHLL
PCIRFKERRL VKLLGMINAI ETVNRSPPLT DVNITLGYRI LDSCSDVDTA VRAMADFMQS
NCSSSAGVQP VTAVIGASHS ETSIAMARQL TLKMIPQISY SSTAVILSDK NRYPAFMRTV
PNDEHQTAAM ASLLSDFGWN WVGIVTTDGN YGQSALDHFV SQASLKGICV AFKSVLPQSV
TSQRIPTVIR HTAETILKNP KVQVIVSFAK PAHMTDLFLE LHRRAGQRME LMKRVWVASD
SWSTSDALKD NLALSDIGHV VGFTFKSDDL SSFNEYLSRL VAAGPKSVKN NPFVQEFYMS
LNSSKGSRDS ELMAEAAAKL KEHAYADTIF GVETAVSAIA QAVASICRNS DCKTPGAVKP
WQVLKALRMK EFQLRGKTYK FDSKGDIDLG YNVIKWRSVR KGYIEVHNVV SEYHLHNNSF
TNTGQHLYNL THIVSKCSNS CMPGEFKKTA EGQHTCCYEC INCTENYYSN DTDMDQCLSC
DVHTEWSHQG SSSCNRKALL FFSWHDGFAI VLVAFSVLGI VLTLLVSALF LHQRETPVVK
ASGGPLSQVI LFSLVISYIS AMMFVGQPNS YQCKVRQVLF GISFTLCVSC ILVKTLQILL
AFQLNPELQL VLRRLYQPYV IVSICVSLQV ATCIAWLVLK SPSNLTIRLP TTLLEYCHEG
SYLAFGVMLG YIAVLALVCF ICAFKGRKLP QHYNEAKFIT FSMLLYLISW MLFVPVYVTT
SGVYLPAVEM VVILISNYGD HPQTQTHGNP PGS
//
