ID   A0A3Q3EX17_KRYMA        Unreviewed;       862 AA.
AC   A0A3Q3EX17;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS   Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX   NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000006182.1, ECO:0000313|Proteomes:UP000264800};
RN   [1] {ECO:0000313|Ensembl:ENSKMAP00000006182.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   RefSeq; XP_017291983.1; XM_017436494.1.
DR   AlphaFoldDB; A0A3Q3EX17; -.
DR   STRING; 37003.ENSKMAP00000006182; -.
DR   Ensembl; ENSKMAT00000006290.1; ENSKMAP00000006182.1; ENSKMAG00000004714.1.
DR   GeneID; 108248033; -.
DR   CTD; 114881; -.
DR   GeneTree; ENSGT00940000157439; -.
DR   OMA; VWESNNI; -.
DR   OrthoDB; 960at2759; -.
DR   Proteomes; UP000264800; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972:SF146; OXYSTEROL-BINDING PROTEIN; 1.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          72..167
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        461..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   862 AA;  96896 MW;  B6BB8C6A194F72EA CRC64;
     MDSNGSSLHR SQSLASGLEK TSPSRTKPAP SHSSSTLSSP HSRQIIKDWE VMDDLQAEIQ
     TGSENPEVLT TPGRCEGYLL KRRKWPLKGW HKRYFVLEAG ILRYSKNQQD VSRGRVQGSL
     DVSLAVMSIN KKSNRIDLDT GDILYHVKAK SHELFYIWVT KLQAHRLYKK NKTSFVHSSL
     LQTLFHTSSA GQAHGNGDLS SAGTEDPAGR SGVPPSASTA VNTKVSAWLR QSHDPDTCVQ
     ELNRCDLDLS ELNRLIQRLQ ALETGHTFTN GDLQRIISIQ NLSLEKPKKL KSGKIRGHSR
     TLSRVEALGM PIRGISKSLS SSHLSSSAHL GASVPSIPDY VYSQLSPPTV LTPEGKKIQQ
     DICAMSLRVL ASLKSVHETL SLERQKLQEA WEANNLHQPN LLDVPAPSLG PPSVTDSAAE
     YFDASDNLLW GSSSEVSDES GLSDGSTTNS EPEEGHASTT RKYRASISRS PNNVVPKSTG
     RRTTLPAPCP DNSHVGLMAI LYNNIGKDLA RVSMPAALNE PVNLLQRLCE ELEYSELLDT
     ANNTPDPFQR MVYIAAFAIS GYTTATFRNR YKPFNPVLGE TYECIREDRG FHFISEQVCH
     HPPISACHAE SENFSFWQDQ RWKNKFWGKS LEIFPTGMVN VTLSRFGDHY EWNKVVTCIH
     NVLSQQRYLE HYGEVTIQNL KNNVCTCKIT FVKSRYWGSD TNKNEVQGTV LDQSGNVIHR
     FGGFWHEGIF CDTLPMPKCI WKPNPQPKDY LLYYGFSTFA MELNELDPDL KPLLPSTDTR
     LRPDQRMLEE GKVSEADKKK DEIEEIQRVR RKELAKRGQE HIPRFFKKAK DSSGRDVWLT
     TGTYWDLREN PGFASLDNLT LW
//