ID A0A3Q3EYD8_9LABR Unreviewed; 626 AA.
AC A0A3Q3EYD8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Netrin 4 {ECO:0000313|Ensembl:ENSLBEP00000011387.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000011387.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000011387.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; A0A3Q3EYD8; -.
DR STRING; 56723.ENSLBEP00000011387; -.
DR Ensembl; ENSLBET00000011978.1; ENSLBEP00000011387.1; ENSLBEG00000008777.1.
DR GeneTree; ENSGT00940000156615; -.
DR InParanoid; A0A3Q3EYD8; -.
DR OrthoDB; 2916807at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF419; NETRIN-4 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..626
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018789756"
FT DOMAIN 30..266
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 336..397
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 398..451
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 502..624
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 365..374
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 425..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 626 AA; 69350 MW; E6551567C3F1445A CRC64;
MLTLLVIILA VLSDAGLSEV FRAGVAPRCE SHACNPRMGN LALGRRVLTQ TVCGNNGTEL
YCSYSDPNVN LACDAATCAK CNAGLPHLSH LAGAMSDSSF RHPNTWWQSA EGVESETVQL
DLEAEFYFTH LILVFRSPRP AAMTLERSQD FGRTWKMLQY FAGNCSATFG LEEGKAGEGW
DSATCTSKYS GTYPCNRGEV IYRTLPKWES LDPFGLEGQQ QLRVTNIRIR LLQRQACPCQ
AKDPASAQED LPTRHFAIYD LIVKGSCFCN GHAEQCVPAR GYQPIRDRTN HVVHGKCVCR
HNTAGDHCEH CAPLYNDRPW QPADGLTGAP HECRKCKCNG HAQSCRFDWP AWRESGQRSG
GVCDCLHNTE GGQCEKCKAG FYRDPQRPQT APDSCKECSC HPLGSMPFHL ADGSLCDPSN
GNCICKPGVG GTHCDRCMVG YWGFHEYGCR PCDCAGDCDP FTGDCMLGSD LDLYNLEGNS
SEPVRIFRVD ELFSALHYSE KCECKEQALT NSKLFCTMNY AYVLKVKVLS AHDKGSHAEV
EVKVQKVLSQ NTKVKIQRGR VTLYPESWTA RGCTCPILNP GVEYLVAGHT DRKQGRLLVN
MKSFVKPWKA SLGRKVLTLL KKDCNW
//
