ID A0A3Q3F088_9LABR Unreviewed; 1161 AA.
AC A0A3Q3F088;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=SH3 and PX domain-containing protein 2A-like {ECO:0000313|Ensembl:ENSLBEP00000012097.1};
GN Name=SH3PXD2A {ECO:0000313|Ensembl:ENSLBEP00000012097.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000012097.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000012097.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SH3PXD2 family.
CC {ECO:0000256|ARBA:ARBA00009628}.
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DR AlphaFoldDB; A0A3Q3F088; -.
DR STRING; 56723.ENSLBEP00000012097; -.
DR Ensembl; ENSLBET00000012726.1; ENSLBEP00000012097.1; ENSLBEG00000009293.1.
DR GeneTree; ENSGT00940000157732; -.
DR InParanoid; A0A3Q3F088; -.
DR OrthoDB; 2910367at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06888; PX_FISH; 1.
DR CDD; cd12074; SH3_Tks5_1; 1.
DR CDD; cd12077; SH3_Tks5_2; 1.
DR CDD; cd12019; SH3_Tks5_4; 1.
DR CDD; cd12020; SH3_Tks5_5; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037961; SH3PXD2_PX.
DR InterPro; IPR035450; SH3PXD2A_SH3_1.
DR InterPro; IPR035452; SH3PXD2A_SH3_2.
DR InterPro; IPR035453; SH3PXD2A_SH3_4.
DR InterPro; IPR035454; SH3PXD2A_SH3_5.
DR PANTHER; PTHR15706:SF22; SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 4.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 5.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..136
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 157..216
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 257..316
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 461..520
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 841..900
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1100..1161
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 520..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1082
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 129752 MW; 26A93559626BE70F CRC64;
MHSLCRVKMQ FRTVLDVKVV DVEKRRNPSK HYVYLINVTY SDNTSHIIYR RYSKFFDLQM
QILDKFPIEG GQKDPKKRII PFLPGKILFR RSHVRDVAMK RLRFIDDYCR ALVRLPPQIS
QSEEVLRFFE TKAEDVNPPV EDYGSKRKSG IDSSEPMVLE QYVAVANYER QENSEISLKA
GETVDVIEKS ESGWWFVSTA EEQGWVPATY LDSQNVTRDD LDLGTSRTGE VTKRRKAHLK
RLDRRWTLGG IVNRQHSREE KYVTIQPYTS QGKDEVSFEK GVTVEVIQKN LEGWWFIRYL
GKEGWAPASY LKKVKEDFSP RKKTLTGPVE IIGNIMEISN LLQKKSVSEK DIQTDGEAGT
SPERHISKSE ISLPMPYNSE INAETGRRLS AGRDTNSPCL GIAASAALRE SKTRGEPGSP
AVARVAPHRV EIGSPNLRQK PPPRREANLG FQLPKPPEPP AVEAEYYTIA DFQSSISDGI
SFRGGQKADV IEKNPGGWWY VQIGEMEGWA PCSYIDKRKK PNLSRRTSTL TRPKVPTPAP
PVKKQNSEET PTPASSVPKV AEPQSRPVYE EPEYDVPAVG CEGESDTDSL KDERSLDVKI
SNVVGDKYRS SPPFCKASPP VCKASPVFTR RRTSFRSVEE VGKEECIYEN DGFRSSSGGK
GTAAKGASEP NSPRIYHSST VPRKPSGSSP LAGRPMKTMT PEMNRRSQTL GRHIDISLRS
QDNSPHSSSD ELTRGPKKVP GFSRDVEQRI GQSPSTRPKP SVRPKPLLTK SEPQTPERMD
IGSLRRQLRP TSQFRHGLKP GRGEDSETAS VISSEDSMCS HSTSDLSSVY SKGSRGDSDV
EGPNHYRSLD AYKKVQDSEI SFPARVEVEV LEKQESGWWY IRWGSEEGWA PSYYLEPVRQ
AADGGRSESD GHGSGGSKSN SLEKNEQHVL ALNNINIQGL NQQHQGMRRN TPAIPSKPPG
GFQKPSGMVN GGVRMRNGVR QVAVRPQSVF VTTTQPAKDA HYMTGSLRRN ESLGRSDHYG
SGSATLGVRR NASFSTVRPH VVVESQTRPV ERSSLGSSGS AFSTSNVQDG LSRVSQRNGI
PVSTVRPKPI EKSQLIHNNL GRDVYVSIAD YRGDEETMGF TEGTCLEVLE RNPNGWWYCQ
VQDSLLPRKG WVPSNYLERK K
//
