ID A0A3Q3F235_KRYMA Unreviewed; 587 AA.
AC A0A3Q3F235;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=APC membrane recruitment protein 2 {ECO:0000256|ARBA:ARBA00039511};
DE AltName: Full=Protein FAM123A {ECO:0000256|ARBA:ARBA00042108};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000007712.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000007712.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of the canonical Wnt signaling pathway
CC involved in neuroectodermal patterning. Acts by specifically binding
CC phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to
CC the cell membrane and interacting with key regulators of the canonical
CC Wnt signaling pathway, such as components of the beta-catenin
CC destruction complex. {ECO:0000256|ARBA:ARBA00037665}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the Amer family.
CC {ECO:0000256|ARBA:ARBA00007750}.
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DR AlphaFoldDB; A0A3Q3F235; -.
DR STRING; 37003.ENSKMAP00000007712; -.
DR Ensembl; ENSKMAT00000007833.1; ENSKMAP00000007712.1; ENSKMAG00000005785.1.
DR GeneTree; ENSGT00530000063529; -.
DR OMA; IDRICLM; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019003; AMER.
DR PANTHER; PTHR22237:SF1; APC MEMBRANE RECRUITMENT PROTEIN 2; 1.
DR PANTHER; PTHR22237; UNCHARACTERIZED; 1.
DR Pfam; PF09422; AMER; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 587 AA; 61875 MW; 652CC4F211802C8F CRC64;
MEVQSECVEP PVAPQCDPQP TGKINKAAFK LFGKRRTGSG MASFFSFRNK GAMNTELVRS
KTHDGLTSTN NDAVGQRGEG VASLEAGPVR SLSKSLSFFS FLRRGSFRTS ENGGAGIVRR
GRGLKGFFSS MRWRRKEKTN EGDGDVAEGK KETDANVAES ENVKDITLTL EPPPHHHQED
CENAEVGPNL QAEDTPTTSV TMTPTHCVAM PGPSAEPDSP LPYTPTDSPL HPPTQKAKAS
ISSLTPSLTT PPLDHCSISD QPSEPSVDRL CSLLFTDVTS LKSFDSLTGC GDIIADADEE
GPAGNGGSGT SSSSSGGGGG SLGASIGRAG GGEEMASPEG VDDADMQGLW HMLPSTGDNS
PALPRLTTKS ADKKAPQVKA LGLSKIPVVG GAGSRAAKPP IPHLLSDEGY WDTPSATPTA
TPDESGLQRN QKIALSRDSC SGDHLYDLYN DPEEEGEDQR GDEDMNSTPS PSTEYKMSPT
SPKSPPSSSS SSSFRSIKGS ASLPRESKIP VSTRQTSPPH SVSQSALSSV LETESSPPKT
QAAPSARTKI PVSKVPVRRS GNKPAITLTE KRAMHLCIFD IFLWNST
//
