ID   A0A3Q3F489_9LABR        Unreviewed;       644 AA.
AC   A0A3Q3F489;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Macrophage-expressed gene 1 protein {ECO:0000256|ARBA:ARBA00021365};
DE   AltName: Full=Perforin-2 {ECO:0000256|ARBA:ARBA00030728};
GN   Name=MPEG1 {ECO:0000313|Ensembl:ENSLBEP00000014444.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000014444.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000014444.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004439}. Cytoplasmic vesicle, phagosome
CC       membrane {ECO:0000256|ARBA:ARBA00004265}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004265}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MPEG1 family.
CC       {ECO:0000256|ARBA:ARBA00007256}.
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DR   AlphaFoldDB; A0A3Q3F489; -.
DR   Ensembl; ENSLBET00000015303.1; ENSLBEP00000014444.1; ENSLBEG00000011074.1.
DR   GeneTree; ENSGT00390000008048; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd22579; MPEG1_P2; 1.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR039707; MPEG1.
DR   PANTHER; PTHR31463; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR   PANTHER; PTHR31463:SF4; MACROPHAGE-EXPRESSED GENE 1 PROTEIN; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00457; MACPF; 1.
PE   3: Inferred from homology;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          131..307
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|SMART:SM00457"
SQ   SEQUENCE   644 AA;  72134 MW;  FB86E5D1969F2AD9 CRC64;
     YLSFLTVPVS RPTNWLRQCR ASANISITAL EVLPGGGWDN LRNMDMGRVM NLSYFECQTT
     EDGLYLIPDE VFVIPHKETG VETNSEIISS WLEQKSSTSN SINADVSFLK MLNGKFSVEN
     QRMKTHQVKD SSTTARVQVR NLIYTVKAYP DFTLDTRFAQ QAKAIADAIE NNQTRNADYL
     SEKMVLDYGT HVITSVDARA TLVEETTSFY HQSTGRVNFF DKLKFDISSQ STQQSSSLQK
     YQSNIQYSLT QSNGGTPFYP GITLQKWQES TRNNLVAIDR SGFPLHYFIN TNTIPDLPHQ
     AIDRYYKVNT RPGCVDINSK NFNFQANIDD SSCEGPATNL SFGGVYQECV QMSSDAGPLC
     DALAQKNLET GEFSCRSPYI STLLRSEVRQ QGYTSYDCYD QRYRCGFLGL SHCHRQVCQD
     NYHVRTARIN TYWCSVNGTA PDNSGYLFGG IYSPSLLNPL TNAKSCPQNF IPVKFLSDGQ
     MICVSKDYET GTRFSVPFGG LFSCQSGNPI SGSQHLSDGC EILYCVQSGL FTGGQLLPIH
     LPPFNKPPLV SMQATNTVMV MTEGDTSWVR VGETKAWKLG HEHENKPSHA EEIVLALGER
     ESEEEGKRDR CIVFKQGNSL FGLFQKQTTD KRVHPAGIQY SPKT
//