ID A0A3Q3F567_9LABR Unreviewed; 2204 AA.
AC A0A3Q3F567;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Low-density lipoprotein receptor-related protein 1-like {ECO:0000313|Ensembl:ENSLBEP00000014743.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000014743.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000014743.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSLBET00000015640.1; ENSLBEP00000014743.1; ENSLBEG00000011476.1.
DR GeneTree; ENSGT00940000162544; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 26.
DR Gene3D; 4.10.1220.10; EGF-type module; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 25.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 23.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00192; LDLa; 27.
DR SMART; SM00135; LY; 8.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 27.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01209; LDLRA_1; 19.
DR PROSITE; PS50068; LDLRA_2; 27.
DR PROSITE; PS51120; LDLRB; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2127..2148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1323..1363
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 1498..1541
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1542..1584
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2082..2118
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 2048..2072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 96..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 136..151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 186..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 292..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 342..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 440..455
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 490..505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 603..618
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 653..668
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 755..770
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 805..820
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 844..859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 883..898
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 929..944
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 969..984
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1026..1041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1065..1080
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1104..1119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1124..1136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1131..1149
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1143..1158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1164..1176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1183..1198
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1225..1240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1245..1257
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1252..1270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2031..2046
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2108..2117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2204 AA; 239849 MW; 26C847875A435FC9 CRC64;
MSLRQERSHQ AGRRWNISGS IIAAYEPFLL SHYNDVMTLW DRRDGTPIQD VIEGGLVFGV
IPALKEIRPV PITPVCNSPS VLCQRTSICL AQTQLCDGKR DCPDGSDEES CVTTCPSKED
FKCKDRSSCI SRSLVCDGRS HCLDGSDEVD CATVASPAPR ANILKCRTGS KPCKDGTECV
LYSHLCDGEE DCRDGSDEQG CGSTEVAPIP ASENLILNDA PLTVTDRPTQ PPCTSPSALC
PGSSLCIKPT QFCDGNRDCP DGSDEKCVKK CQYKSDYLCK DRRSCVSKKL VCDGRSHCND
GSDERNCPDV ATPAARAKSF KCRIGSKPCN DGKECVIFSH VCDGERDCQD GSDELGCEII
GTSESPALME PVTEPPTRPP CTSPSALCPG SYLCIKPTQF CDGKRDCPDG SDEKCVKRCP
DRSFFLCKDR RSCVPKKLVC DGRSHCNDGS DEINCPDVVA PVTQAKSLKC RMGSKLCNDG
TECVLFSHVC DGERDCRDGS DELGCDAATT IHAETPQLTE SPIIVNETPL PVEPFTEPPT
QPPCTSPSVL CPDSSVCLKP TQFCDGKKDC PDGFDEKCVK RCPDRTDFRC KDRRSCVSKR
LVCDGRSHCN DGSDELGCPS VSSTAAPPKT LKCRMGSRLC NNGTECVLYS HVCDGERDCR
DGSDEEGCDD LSTVTSAASE KLSLNEASLP LTEAPCTSPS VLCPGSSFCI KPTQFCDGKR
DCPDGSDENC LEKCQDSSDF LCKDRRSCVS ETLVCDGRSH CNDGSDEYNC PDVAAPVTQA
KSLKCRIGAK SCNDGKECVL YSHVCDGERD CMDGSDEQGC PGTCKQDEFQ CFHGKMCIPL
AQVCDGKPQC QDQTDELNCQ EQTNSCEYHC KDGKRCIPKK FLCDGERDCL DGTDEVGCDS
TVLKFTPPCI SPSVICPNSS LCIAQNQLCD GRKDCPDGFD EKNCILQCTN PDDFLCSDRR
ACVLRRELCD GRSHCPDGSD ERWCRSADAT APSSSVLAAS SNPLKCRRGL KPCKDGLECV
LYSHVCDGER DCKDGSDEEG CAAQCKADEF ECAHGNRCIP LDKVCDGQND CQDLSDEKEC
SSLIEGCHHR CDNNTRCVPK TFLCDGERDC ADGSDEEKCA LVACAIHQFR CASGQCVSEA
LRCDGYADCS DRSDEVDCTR PPRCPAQLQC PNSHECLQKE WLCDGENDCK DGSDEKNCVS
APAKCRDYQW QCRDSSQCIP LSWLCDGKAD CDNGMDEDKC GEKKCPSHLY QCGSGECLDP
HLVCNSYTNC ADRSDEGPGC VKSNCSSSSA PECDHHCTST PNGPRCYCAA GYITHVNTVS
CVDIKECNLM PYMCKHTCLN TLGSYICQCH PGFYLEPDNK SCKTKDEPLL LASVQSELLL
LGIHSGTLRL LSSASRPVFS LDYHWAQERV YWLSPDYQSI RWADMTNPKN HGTLIKGVKL
DFIAVDWVGK NLYWVDGLVG QILAVKLSDA TVRSHDYTVV LGVGLEQPSS LVLLPHKGLM
LWSEIGSTPQ IERSGMDGSK RKVVVSQGLR WPVGLAFDLL ENRVYWADEK LRCIGSTSLD
GDNIKILQLV ETPSPFSVAV FNDKVFWSDT KRRTIRSADK NTGKDQKVLL KRPGQPFGLK
VMHALSQPAI QSPCGQLKCS HICLLAPPVT TRSQAPAAGT GPTAICRCPK GLLLSKDKIT
CSLPVETTFI MLLSHATVYQ IHLRSIRRDG VALKKMPNGR NLALPGISEA SGFDVFLQDL
SLYVADAGQG SVDVLTLSSS MSRPELTSSG KILKLKDDLV TALAVDWVTS NLYWSSIERP
NLHVTSRHNG YNTSLMQGSL KGITSMAVHP PTGRLCYTAI VVEVETSQTE VNCAWMDGRN
KAVLWRKSSI PTALVFANQG TMIYWADTGE SVISSIGVDG SGYKQHKTGP GLIMSFTYIE
NILLWVSLDK DVTKLWFSDG LQPNQLWFET KTSLVEVRAY SNDSQSDTNS CSNNNGGCDH
LCLAYPGGRT CKCGLGSSAV NASSCASLPD CPAEQQSCLD GSECISSSKF CDGHLDCSDE
SDEQDCPNTD SASFWTKPND GRPQKLPSSP HLNANVNSVK TDPSSCEVQR CNSHGSCVNE
GKDTRCNCVA GYKGQFCAET VTGGSKVGVV LGVLCLVSAL TAAAFIYAKR RGWATVRSRS
IEKETLMANM GLPCEHYYDS DSEELDSPVD VKNPPMALKP LQLK
//
