ID A0A3Q3F743_9LABR Unreviewed; 1189 AA.
AC A0A3Q3F743;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000015399.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000015399.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q3F743; -.
DR Ensembl; ENSLBET00000016322.1; ENSLBEP00000015399.1; ENSLBEG00000011490.1.
DR GeneTree; ENSGT00940000155510; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd17971; DEXHc_DHX8; 1.
DR CDD; cd21691; GH2-like_DHX8; 1.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044762; DHX8/Prp22_DEXHc.
DR InterPro; IPR049588; DHX8_GH2-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 238..309
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 544..707
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 725..905
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 100..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..198
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..232
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 135278 MW; 43EB3547CFA030B1 CRC64;
MAASDEIKRL EYLSLVSKVC TELENHLGIS EKDLAEFIIS LAEKHPTFED FKAVLSKNGA
DFTDTLTGNL LRLIHTMRPQ PSTSKEFKPD REKGKLIEKY PALCKPDDPI PPSQPDKDDE
HVAAAAMKEL EMLMPNFSGT SSDNRSFKRK CSARPSQGDR GRGTEGQSGR KRSRSRSRDR
EGEAIPKQRR KRVSRWSDHP PSPSRVVVNN NNNKEDKDSD RCRDRLVDRP PPEEPVVGDI
YIGKISSIMQ FGCFVQLEGL RKRWEGLVHI SELRKEGRIA NVADVVSRGQ KVKVKVLSFT
GTKASLSMKD VDQETGEDLN PNRRRNLDTG PGEEAMRNPD RPVEASMLEL EENTTERKRL
TKITDLEKWE VKQMIAANVL PREEYPEFDE ETGILPKIDD DEDEDMDIDL VEEEPPFLRG
QTKWSTNMSP VKIVKNPDGS LSQAAMMQSA LSKERRELKQ AARAAEMDSI PTGLHKNWID
PMPDYEGRQI AANMRGIGAM PLDLPAWKKY AFGGNQVSYG KKTEMSILQQ RESLPIFKLK
EQLVQAVNDN QILIVVGETG SGKTTQITQY LAEAGYTARG KIGCTQPRRV AAMSVAKRVS
EEYGCRLGQE VGYTIRFEDC TCTETVIKYM THGMLQRECL IDPDMSQYSL IMLDEAHERT
IHTDVLFGLL KKTIKKRKDM KLIVSSATLD AVKFSQYFFE APIFTIPGRT FPVEVLYTKE
PETDYLDAGL ITVMQIHLTE PPGDVLVFLT GQEEIDTACE ILYDRMKSLG PDVPELIILP
VYSALPSEMQ TRIFDPAPPG SRKVIIATNI AETSLTIDGI YYVVDPGFVK QIVYNSKTGI
DQLVVTPISQ AQAKQRSGRA GRTGPGKCYR LYTERAYRDE MLTTNVPEIQ RTNLASTVLS
LKAMGINDLL AFDFMDAPPM ETLITAMEQL YTLGALDDEG LLTRLGRRMA EFPLEPMLCK
MLIMSVHLGC SEEMLTIVSM LSVQNIFYRP KDKQALADQK KTKFFQLEGD HLTLLAVYNS
WKNNKFSNPW CFENFIQARS LKRAMDIRKQ MLSIMDRHKL DVVSCGKSSM RVQKAICSGF
FRNAARKHPH DGYRTLIDQQ VVYLHPSSTL FNRQPEWLVY HELVLTTKEY MREVTTIDPR
WLVEFAPAFY RVGDPTRLSR QKRQQKLEPL YNRYEEPNAW RISRAFRRR
//
