ID A0A3Q3FB44_KRYMA Unreviewed; 1200 AA.
AC A0A3Q3FB44;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ret proto-oncogene {ECO:0000313|Ensembl:ENSKMAP00000010592.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000010592.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000010592.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q3FB44; -.
DR STRING; 37003.ENSKMAP00000010592; -.
DR Ensembl; ENSKMAT00000010754.1; ENSKMAP00000010592.1; ENSKMAG00000007897.1.
DR GeneTree; ENSGT00940000158499; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0014707; P:branchiomeric skeletal muscle development; IEA:Ensembl.
DR GO; GO:0048484; P:enteric nervous system development; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; IEA:Ensembl.
DR GO; GO:0072114; P:pronephros morphogenesis; IEA:Ensembl.
DR GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 2.
DR CDD; cd05045; PTKc_RET; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041163; Ret_CLD1.
DR InterPro; IPR040667; Ret_CLD3.
DR InterPro; IPR041317; RET_CLD4.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF485; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF17756; RET_CLD1; 1.
DR Pfam; PF17812; RET_CLD3; 1.
DR Pfam; PF17813; RET_CLD4; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00112; CA; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49313; Cadherin-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50268; CADHERIN_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Kinase {ECO:0000256|ARBA:ARBA00023137}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 53..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 257..354
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 810..1102
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 13..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 844
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1200 AA; 134965 MW; 4781E48515EE821B CRC64;
MKLCVVHVVQ PAAAPPPPHR HSAQLQPQDR HTAAPPWDSE DIWLPGAAGH TPLLTPPLCF
LSLFFFFFFT ERNFWDPCFR WETFPSCFVD METNCGFCQG IAAVLRMLLL LGGVAGLYFP
QKEYMETVYV GQPAGTPVLQ VHAMLDSESE TPHFYLCESR NPSFSSWFHM NVGTGLLVLR
KALEEADFSS LSQNSWQRKK LTLKAAVSNA VVKRSQCSPL KTAHITLEFV NASVPNCAQM
DLNEFCFPHM DASNPHVKEN RFPGALRQLR QLTRLNVCPN YTVSYSVESA ETPALFDVNG
NTTELVVTAA LDREEGEKYK LLMVCTVQSD TAITKVDASL EVLVDDEDDN APYVNGTDTA
DVVINYNRKK GATFGSLFVF DRDLTTIYPK DQSGNKFVET FLSSDPWIKE TFDIKGTFSE
RKAAPGGVRE SVFNYQLVLK KNLHVTENRS VYLEYRVNDT SYPGLEGTVL LHFNVTILPV
QIHFANRTYV FTLSRRASLY AQVGRVCVEN CLQFDGFSVT YQLEAPDNTS ADSLFCYSAV
TVTRSSDGVQ GVLFVNNSEA LRRCPDLLYA VVAQEGQTQL EASAQIHVVL EGEANRTRED
TPQLLSCAEN RQRGECESSP GLGAMTGTCQ WRQGSDKEIT KNYSTCSPDL RTCPDAICDA
VESKDLSICP QDCTREGVIG GFEPGLSGYG IKAGHGTCYC FSEKCFCEKM EEFIREEVIC
DDMCKTIIAT ALLLSFIVSI LLSSYFIHRY HKKSPKPPIA SAEMTFRRPA QVYPISFPAN
NLRRGSQESI ETDTFKIPED PKWEFPRKNL VLGKTLGEGE FGKVVKATAF RLKGKVGYTT
VAVKMLKENA SHSELRDLLS EFTLLKQVNH PHVIKMYGAC SQDGPLYLIV EYAKYGSLRN
FLRESRKVGP SYMGRDANRN SSYLENPDDR ALTMGDLISF AWQISRGMQY LAEMKLVHRD
LAARNVLVAE GRKMKISDFG LSRDVYEEDS YVKRSKGRIP VKWMAIESLF DHIYTTQSDV
WSFGVLLWEI VTLGGNPYPG IAPERLFNLL KTGYRMEKPE NCSEEMYNLM LRCWKQESDK
RPTFSDISKE LEKMMVKSRD YLDLAASTPA DALLYDDTLS EEDTPLVDCN NAPVPRTLPS
TWIENKLYGM SYPNWPEKSP VLLNRHDATN PVFTRYANDS VYANWMALPS PAKAVDKLDS
//
