ID   A0A3Q3FE23_9LABR        Unreviewed;       459 AA.
AC   A0A3Q3FE23;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Chimaerin {ECO:0000256|PIRNR:PIRNR038015};
DE   AltName: Full=Chimerin {ECO:0000256|PIRNR:PIRNR038015};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000018391.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000018391.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: GTPase-activating protein for p21-rac.
CC       {ECO:0000256|PIRNR:PIRNR038015}.
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DR   AlphaFoldDB; A0A3Q3FE23; -.
DR   STRING; 56723.ENSLBEP00000018391; -.
DR   Ensembl; ENSLBET00000019416.1; ENSLBEP00000018391.1; ENSLBEG00000014165.1.
DR   GeneTree; ENSGT01030000234635; -.
DR   InParanoid; A0A3Q3FE23; -.
DR   OrthoDB; 5395569at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0001565; F:phorbol ester receptor activity; IEA:Ensembl.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0021623; P:oculomotor nerve formation; IEA:Ensembl.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProtKB-UniRule.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04372; RhoGAP_chimaerin; 1.
DR   CDD; cd10352; SH2_a2chimerin_b2chimerin; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR035840; Chimaerin_SH2.
DR   InterPro; IPR017356; CHN1/CHN2.
DR   InterPro; IPR020454; DAG/PE-bd.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037860; RhoGAP_chimaerin.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR46075:SF1; N-CHIMAERIN; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PIRSF; PIRSF038015; N-chimaerin; 1.
DR   PRINTS; PR00008; DAGPEDOMAIN.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   GTPase activation {ECO:0000256|PIRNR:PIRNR038015};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRNR:PIRNR038015};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          49..117
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          205..255
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   DOMAIN          268..459
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
SQ   SEQUENCE   459 AA;  52714 MW;  A05436069E07489C CRC64;
     MALNVFDHDE YRPPVWKSYL YQLQQEAPHP RRLTCTCEVN NRPKYYGREY HGMISREEAD
     QLLSQAEGSY LIRESQRQPG TYTLALRFGN QTRNFRLYHD GKHFVGEKRF ESIHDLVTDG
     LITLYIETKA AEYIAKMTIN PIYEHVGYTT LNQEPTLKKH LPLSPEAPDG PAPAKDDCNA
     EERLTSLVRR ATLRESDLAP KYEKVHNFKV HTFRGPHWCE YCANFMWGLI AQGVKCADCG
     LNVHKQCSKV VPNDCQPDLR HVKKVYSCDL TTLVKAHNTK RPMVVDMCIQ EIEARGLQSE
     GLYRISGFSE LIEDVKLAFD RDGEKADISS NAYEDINCIT GALKLYFREL PIPLITYDAH
     PRFIEAAKIT DPEKRLEAVH EALKLLPPAH CETLRYLMAH LKRVIQAEKE NLMTSENLGI
     VFGPTLMRAP ELDAMTALND IRYQRLVVET LITNEDVLF
//