ID A0A3Q3FEF7_9LABR Unreviewed; 738 AA.
AC A0A3Q3FEF7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN Name=MTRR {ECO:0000313|Ensembl:ENSLBEP00000017623.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000017623.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000017623.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR AlphaFoldDB; A0A3Q3FEF7; -.
DR STRING; 56723.ENSLBEP00000017623; -.
DR Ensembl; ENSLBET00000018611.1; ENSLBEP00000017623.1; ENSLBEG00000013602.1.
DR GeneTree; ENSGT00940000155822; -.
DR InParanoid; A0A3Q3FEF7; -.
DR OrthoDB; 276396at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06203; methionine_synthase_red; 1.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 9..152
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 317..575
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 738 AA; 81015 MW; A4C7CF3F8070E53F CRC64;
MPCEVKPRFV VLYGSQKGQA QSIAEGIAEE AEQHGLVAEL SCLDQNDKYD LEKESAPVVF
VVSTTGDGEP PDNTLQFVKS IKKKTLPADH YKHLCYALLA LGDTNYANFC NCGKTIERRL
QELGAEQFYA TGYADDGVGL EVVLDPWLEG LWKAIKAALS KMASDRTSCL KGEAGESTKE
DSSIPDVQLS LLSITDQQNC NSANSSLETV SKFASAASSS ASATQTAVSD LVPATPLGSD
GLASQFHDAA SVSTSKQETQ TGDAGVPGVA LAASLTRSLP PLSESSLNVP ALPPSYLDVS
LQEAEIIEQV DGPANRDSLH EVPISRAVQL TRGDSVKTAL CLELDISLMS YQPGDSFDVF
CPNRASEVED MLHGLALSDQ RNHLVNISLR KDTKKKGALV PPYIPQNISL LYLLTWCLEI
RSVPKKAFLR ALVEHTGDSV QKRRLQELCS KQGAADYNLF VRDPSLSILE LFAAFPSCSP
PLSLLIEHVP KLQPRPYSAA SSCLRHPGKL HFVFNIVEFP ACSVRPAGRQ GLCTGWLFDL
IRPVLVFPEK DESSSSTDLP KIRVKLRPNC SFRPPSDPSV PFIMVGPGTG VAPFIGFLQQ
REKEKQEKPK ATFGETWLFY GCRHRDRDFL FREELEGFVS SGTLSHLKVC FSRDSGEEDG
RPKYVQDNLL INRQHVTDIL LKQNGYLFVC GDAKNMAKDV NDALIEMIKK ELQVDQLDAM
KTLAGLREEK RYLQDIWG
//