ID   A0A3Q3FEF7_9LABR        Unreviewed;       738 AA.
AC   A0A3Q3FEF7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE            EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN   Name=MTRR {ECO:0000313|Ensembl:ENSLBEP00000017623.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000017623.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000017623.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR   AlphaFoldDB; A0A3Q3FEF7; -.
DR   STRING; 56723.ENSLBEP00000017623; -.
DR   Ensembl; ENSLBET00000018611.1; ENSLBEP00000017623.1; ENSLBEG00000013602.1.
DR   GeneTree; ENSGT00940000155822; -.
DR   InParanoid; A0A3Q3FEF7; -.
DR   OrthoDB; 276396at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd06203; methionine_synthase_red; 1.
DR   Gene3D; 3.40.50.360; -; 1.
DR   Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 1.
DR   InterPro; IPR003097; CysJ-like_FAD-binding.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR001094; Flavdoxin-like.
DR   InterPro; IPR008254; Flavodoxin/NO_synth.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR   PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR   Pfam; PF00667; FAD_binding_1; 1.
DR   Pfam; PF00258; Flavodoxin_1; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PRINTS; PR00369; FLAVODOXIN.
DR   PRINTS; PR00371; FPNCR.
DR   SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR   SUPFAM; SSF52218; Flavoproteins; 1.
DR   SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   FMN {ECO:0000256|ARBA:ARBA00022643};
KW   Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT   DOMAIN          9..152
FT                   /note="Flavodoxin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50902"
FT   DOMAIN          317..575
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51384"
SQ   SEQUENCE   738 AA;  81015 MW;  A4C7CF3F8070E53F CRC64;
     MPCEVKPRFV VLYGSQKGQA QSIAEGIAEE AEQHGLVAEL SCLDQNDKYD LEKESAPVVF
     VVSTTGDGEP PDNTLQFVKS IKKKTLPADH YKHLCYALLA LGDTNYANFC NCGKTIERRL
     QELGAEQFYA TGYADDGVGL EVVLDPWLEG LWKAIKAALS KMASDRTSCL KGEAGESTKE
     DSSIPDVQLS LLSITDQQNC NSANSSLETV SKFASAASSS ASATQTAVSD LVPATPLGSD
     GLASQFHDAA SVSTSKQETQ TGDAGVPGVA LAASLTRSLP PLSESSLNVP ALPPSYLDVS
     LQEAEIIEQV DGPANRDSLH EVPISRAVQL TRGDSVKTAL CLELDISLMS YQPGDSFDVF
     CPNRASEVED MLHGLALSDQ RNHLVNISLR KDTKKKGALV PPYIPQNISL LYLLTWCLEI
     RSVPKKAFLR ALVEHTGDSV QKRRLQELCS KQGAADYNLF VRDPSLSILE LFAAFPSCSP
     PLSLLIEHVP KLQPRPYSAA SSCLRHPGKL HFVFNIVEFP ACSVRPAGRQ GLCTGWLFDL
     IRPVLVFPEK DESSSSTDLP KIRVKLRPNC SFRPPSDPSV PFIMVGPGTG VAPFIGFLQQ
     REKEKQEKPK ATFGETWLFY GCRHRDRDFL FREELEGFVS SGTLSHLKVC FSRDSGEEDG
     RPKYVQDNLL INRQHVTDIL LKQNGYLFVC GDAKNMAKDV NDALIEMIKK ELQVDQLDAM
     KTLAGLREEK RYLQDIWG
//