ID A0A3Q3FGD7_KRYMA Unreviewed; 437 AA.
AC A0A3Q3FGD7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=5-hydroxytryptamine receptor 3A-like {ECO:0000313|Ensembl:ENSKMAP00000012237.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000012237.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000012237.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017291460.1; XM_017435971.1.
DR AlphaFoldDB; A0A3Q3FGD7; -.
DR Ensembl; ENSKMAT00000012421.1; ENSKMAP00000012237.1; ENSKMAG00000009202.1.
DR GeneID; 108247659; -.
DR KEGG; kmr:108247659; -.
DR GeneTree; ENSGT00940000163471; -.
DR OMA; LETILMM; -.
DR OrthoDB; 5489962at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF786; 5-HYDROXYTRYPTAMINE RECEPTOR 3A-LIKE-RELATED; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..437
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018759843"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..237
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 246..341
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 437 AA; 50516 MW; 5D6C45BEDC509518 CRC64;
MLQTNFLLLL LLIAIDGDSS EKVCSYQDVL NYLKLSKSNE LFSMTRPVKD FRQPTEVILE
ILLYAILDVK EIDQTFVPYV WIILRWQNDY IFWDPNEFCG ISNVTIPTDI LWKPDLTIEE
MTEKDKAPPS PHLTIRSNGE VLVQNDQVLV STCRMQVYKF PFDMQSCNLS VKSVVHSVSE
IRLKHHLNSS GATNWSRQLM RTQYEWLFVN LTITTKTVFP FGVEQDVIIY TIFMKRRAKL
YIINFLLPIL FLLFLDLASF LVPDRGGEKL SFKVTVLLAV TVMQLILNDI LPSSSDKTPL
IEVYCFGIFA LMMLSLLETI VMMYLMEKES ACPNGEKKWN RCSCLCGVSA ENMPSVLTEG
SGSELTREQE VSDKFPEELK EFVKTATLLL VNMKEEEKPG FWTRKSQFIN TTYFIFYVTA
ASLFLGYTYY CWFDAKE
//
