ID   A0A3Q3FI09_9LABR        Unreviewed;       989 AA.
AC   A0A3Q3FI09;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Sorting nexin 14 {ECO:0000313|Ensembl:ENSLBEP00000019139.1};
GN   Name=SNX14 {ECO:0000313|Ensembl:ENSLBEP00000019139.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000019139.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000019139.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   AlphaFoldDB; A0A3Q3FI09; -.
DR   STRING; 56723.ENSLBEP00000019139; -.
DR   Ensembl; ENSLBET00000020173.1; ENSLBEP00000019139.1; ENSLBEG00000014597.1.
DR   GeneTree; ENSGT00950000182856; -.
DR   InParanoid; A0A3Q3FI09; -.
DR   OrthoDB; 2877434at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:InterPro.
DR   CDD; cd06877; PX_SNX14; 1.
DR   CDD; cd08722; RGS_SNX14; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037436; SNX14_PX.
DR   InterPro; IPR037892; SNX14_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF44; SORTING NEXIN-14; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        27..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        51..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          128..302
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          334..466
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          612..732
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          528..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   989 AA;  114590 MW;  F68A548757412599 CRC64;
     MGCITTFLHK IRRRMKLERF RELGRQYPVF CFLLLVLLLT TLLLNRYIHI IMVFWSFLAG
     VITFYCSLGP ESLLPNIFVS IKPKNKTYQQ ELFPLGHSCA VCGKIKCKRH RPTLLLENYQ
     PWLDLKVPSK VDASLSEILE LVLENFVYPW YRDITDDEAF VDELRVTLRF FAAVLVRRTQ
     KVDVALLITQ KLLKVSMKHI EIISKARQRV KNSEFLQQAA LEEYGPDLHV ALRSRRDELL
     YLRKLTEMLF PYILPPKATD CRSLTLLIRE VLAGSVFLPS LDYLADPDTV NHLLLLFIDN
     SPPEAATEPS STLVPFLQKY SDTRSKKPSV LKLELKEIRE QQDLLFRFMN FLKQEGAVHV
     LQFCLAVEEF NDRILCPELS DSEKVLLHGE VKKIYESYCL DESIDKIRFD PFIVEEIRNI
     AEGPYAEVVK LQTMRCLFEA YEHVLSLLEN VFTPMFCHSD EYFRQLLRGA ESPTRNSKMS
     RNSLSLDDIR SWDWSPESPS SLFTASGSSS PASFNSLHAQ STFTTLPYGS LSHRHSSPKN
     TSKRGESFGI SRIGSKIKGV FKSTTMEGAM LPSYGLVEGE DDMVEEAMMV LEDDAPMEAA
     STPSTPRNLS AWNITIPYID FYDDDVKRER IPVFCIDVER NDRKAVGHET EHWSVYRRYL
     EFYVLESKLT EFHGSFPDAQ LPSKRIIGPK NYEFLTSKRE EFQEYLQKLL QHPELSNSQL
     LADFLSPYSM ESQFLDKMLP DVNLGKIIKS VPSKLIKEKG QHLEPFIQSF FNSCESPKPK
     PSRPELTILS PTSENDKKLF NDVFKNNANR SELSEKRHNQ NYFMEMINVE GVYDYLMYIG
     RVVFHIPDWL HHLLMTGRIL LKNTLEAYTD YCLQYKLNQV VQEHRLVSLI TLLRDSVFCE
     SSQPRSAQDK QSRARKTFDE MMKYIPDFLG KCIGEEAKYE GIRLLFDGLQ QPVLNKQLTY
     VLLDITIQEL FPELNKQVQK ETSVMAPWM
//