ID A0A3Q3FIQ9_9LABR Unreviewed; 756 AA.
AC A0A3Q3FIQ9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neurofilament heavy {ECO:0000313|Ensembl:ENSLBEP00000019394.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000019394.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000019394.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; A0A3Q3FIQ9; -.
DR STRING; 56723.ENSLBEP00000019394; -.
DR Ensembl; ENSLBET00000020445.1; ENSLBEP00000019394.1; ENSLBEG00000014345.1.
DR GeneTree; ENSGT00940000154418; -.
DR InParanoid; A0A3Q3FIQ9; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005883; C:neurofilament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0061564; P:axon development; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR InterPro; IPR033183; NF-H.
DR PANTHER; PTHR23214:SF1; NEUROFILAMENT HEAVY POLYPEPTIDE; 1.
DR PANTHER; PTHR23214; NEUROFILAMENT TRIPLET H PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660}.
FT DOMAIN 57..368
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 14..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 68..211
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..491
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..756
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 86409 MW; 409F470D0F037EE7 CRC64;
MSFMEHHLFG PGSYRKARPA SVSSSGFHSQ RRRLIYSQPP SVDSLETFNG DMTRRNEKEI
LQTLNDRFAG YIEKVRNLEM HNRNLEAEAA ALRQNQAGRT SVGEHYEREL GDLRGLLQQL
TGEKACVALE HEHLEEDIQH LRARLEDEAR NREELEAAAR TMKKYVEECR LARLELDKKL
RALEEEDAFL KKNHEEEVAE LLAQIQGAQV SFDMRDSLKT DVTAALREIR TQLDTHTNKS
STHAEEWFKV RMDRLSDAAR SNQDAIRGSQ EEIGEYRRQL QSRTIELETL RGTKESLDRQ
RMESEDRHHD DLNSLQETIN QLDNELKTTK WEMASQLRDY QELLNVKMAL DIEIAAYRKL
LEGEENRFVS GGSPFSYLEG RFSSHFKVKG EEISDTVIVE EQTDETQVTE VTEEADDEEE
EEEKEEEEEG EETKDEAGEG EEGENKEEGE EEKEEEKGAE EEEGENKEEA GEEAGEEAGE
EAGEEAGEEA GEEAEDKSKS PEKGASPPSK SPQPKSPAVE SHKNHQKNHQ QPNPLFPNHP
LNRLQPNLRQ QMSQSHLKWP SLKEKKEEKK EEKKEPVSEE KKEKEQPVKE EKKQEPKEKE
PEKSEKPDIK KDTKADDSTK PVTPSKPAEE KPSPKSEPKD SAPPAKEEKP SAPKSEAKPE
VKPTSKPQPE ATESSKKEEK KSEEKAVPTA EPVKAESKKE EKKPEEKKPE EKKEASKEES
KETKDEGKAE KSSSTESKES KEEKAPEEEM PKNYEC
//
