ID A0A3Q3FM43_9LABR Unreviewed; 896 AA.
AC A0A3Q3FM43;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Aminopeptidase {ECO:0000256|RuleBase:RU364040};
DE EC=3.4.11.- {ECO:0000256|RuleBase:RU364040};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000020762.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000020762.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR634016-3,
CC ECO:0000256|RuleBase:RU364040};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634016-3,
CC ECO:0000256|RuleBase:RU364040};
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136, ECO:0000256|RuleBase:RU364040}.
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DR AlphaFoldDB; A0A3Q3FM43; -.
DR STRING; 56723.ENSLBEP00000020762; -.
DR Ensembl; ENSLBET00000021890.1; ENSLBEP00000020762.1; ENSLBEG00000015944.1.
DR GeneTree; ENSGT00940000159086; -.
DR InParanoid; A0A3Q3FM43; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09601; M1_APN-Q_like; 1.
DR Gene3D; 1.25.50.20; -; 1.
DR Gene3D; 2.60.40.1910; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR024571; ERAP1-like_C_dom.
DR InterPro; IPR034016; M1_APN-typ.
DR InterPro; IPR001930; Peptidase_M1.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533:SF156; ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR Pfam; PF11838; ERAP1_C; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR PRINTS; PR00756; ALADIPTASE.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000256|RuleBase:RU364040};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364040};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR634016-3};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU364040};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU364040};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRSR:PIRSR634016-3}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..896
FT /note="Aminopeptidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018603592"
FT DOMAIN 53..235
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 261..474
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT DOMAIN 547..867
FT /note="ERAP1-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11838"
FT ACT_SITE 327
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-1"
FT BINDING 326
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT BINDING 330
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT BINDING 349
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-3"
FT SITE 411
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR634016-4"
SQ SEQUENCE 896 AA; 102909 MW; C006E110C55913D4 CRC64;
MFVAPLLLLL SLPFPPSSGA QLPNQNQAKH VPVATNGQPF PWHHMRLPKT VSPLHYDLSV
HPNLTTLDFT GIVRIQLNVL EDTRTIVLHA KKMQISNVLL LAPEGVRPLQ VLEYPPFHQL
ALRSDSVLTR GRRYEVQLQF AANLSDSFHG FYKGSYRTSS GEDRVLASTQ FEATFARGAF
PCFDEPAFKA NFTIRIIREP RHIAISNMPK VKTVELPGGL LEDHFDTSVQ MSTYLVAYIV
SDFSSVSRTT QHGVKISVYA VLLDFYDDYF DIPYPLPKQD LAAIPDFQSG AMENWGLTTY
RETGLLFDPD RSSASDKLGI TKVIAHELAH QWFGNLVTME WWNDLWLNEG FAKFMEFISL
DITYPELQVD DFFLGKCFEA MEVDSLSSSH PVSTHVENPT QIQEMFDDVS YDKGACILNM
LRDFLTPDAF EIGIIRYLKR YSYQNTVNSH LWESLTDKWF SGDELDVRAI MDTWTLQEGF
PLVTVEVRGR EVRLSQERYL KTDDPSLTEG FLWQIPLTYM TSASSTIHRF LLKTKTDVLY
LPEEVDWVKF NVDMSGYYMV HYTGQGWNSI IKVLQHNHTA LSSNDRASLI HNVFQLVSIG
KVRLDTALEL SLYLSRETEI MAVTQGFGEL VPLYKLMEKR DMAALENQMK GYIVDLFHGL
MDRQEWTDSG SVSERMLRSY LLLFGCVRNY APCVKKATQL FSQWKDSDGK MSLPVDVTMA
VFMVGVRTPE GWDFLFEKYR SSLQMSVRSR MKSAMAYSPL KDKLQWMMEQ SLQGEVMKTQ
DLPDVIVTVS KNPYGYQLGW EFLKANWHTM IKKFDLGSST ISYLVTGVTN QYSTREKLDE
VRSFFGSLTE ETGSEMRCIR QTYETIEDNI RWMDTNVPLL QAWLDKRGHR VLHEDL
//
