ID A0A3Q3FPT4_9LABR Unreviewed; 1380 AA.
AC A0A3Q3FPT4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000022531.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000022531.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|RuleBase:RU004279};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|ARBA:ARBA00006460, ECO:0000256|RuleBase:RU004279}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 56723.ENSLBEP00000022531; -.
DR Ensembl; ENSLBET00000023712.1; ENSLBEP00000022531.1; ENSLBEG00000017214.1.
DR GeneTree; ENSGT00930000151028; -.
DR InParanoid; A0A3Q3FPT4; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02736; RNAP_III_Rpc1_C; 1.
DR CDD; cd02583; RNAP_III_RPC1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 6.20.50.80; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR035698; RNAP_III_Rpc1_C.
DR InterPro; IPR035697; RNAP_III_RPC1_N.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF32; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 248..543
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1380 AA; 154671 MW; D26B2A030B9AC74B CRC64;
MVKEQFRETD VAKKISHICF GMKSAEQMRQ QAHIQVVSKN LYSQDTKHTP LSYGVLDHRM
GTSEKDRPCL TCGKNLADCL GHYGYLDLEL PCFHVGYFKA IIGILQMICR TCSSIMLSKE
DKLQFMDHLK RPTLTYLQKR GLKKKISDKC RKRTICLSCS AFNGPVKKCG LLKIIHEKYK
TTKKVVDPFV SEFMQSFDTA IEHNKVMEPL LTRAQENLNP LVVLNMFKRI PQEDIPLLLM
NPEAGKPADL ILTRLLVPPL CIRPSVVSDL KSGTNEDDLT MKLTEIIFLN DVIKKHRMTG
AKTQMIMEDW DFLQLQCALY INSELSGIPL NMAPKKWTRG FVQRLKGKQG RFRGNLSGKR
VDFSGRTVIS PDPNLRIDEV AVPVHVAKIL TYPEKVNKAN LELMRKLVRN GPEVHPGANF
IQNLRKPRED GQELRFGDVV ERHLKDGDIV LFNRQPSLHK LSIMAHIARV KPHRTFRFNE
CVCTPYNADF DGDEMNLHLP QTEEAKAEAL VLMGTKANLV TPRNGEPLIA AIQDFLTGAY
LLTLKDTFFE RSKACQIVAS ILVGKDEKVR ISLPRPSIMK PMALWTGKQI FSLILRPGKD
SPVKANLRTK GKQYCGKGED LCYNDSFVVI HNSELMCGTM DKGTLGSGSK NNIFYILLRD
WGQLEAANAM SRLARLAPVY LSNRGFSIGI GDVTPGQGLL QAKHELLDDG YKKCDEYIEA
LKTGKLQQQP GCTAEETLEA LILRELSVIR DRAGSACLRE LDKSNSPLIM ALCGSKGSFI
NISQMIACVG QQAISGSRVP DGFENRSLPH FEKHSKLPAA KGFVADSFYD GLTPTEFFFH
TMAGREGLVD TAVKTAETGY MQRRLVKSLE DLCSQYDLTV RSSTGDIIQF IYGGDGLDPA
AMEGKDEPLE FKRVLDNIRA VYTCPNEPAL SQNELVLTAD AIMKRVDFKC CRDSFLEEIK
KFIKSISERI KKTRDKYGIN DNGTSEPKVL YQLDRITPTQ LEKFLETCRD KYMRAQMEPG
SAVGALCAQS IGEPGTQMTL KTFHFAGVAS MNITLGVPRI KEIINASKNI STPIITAHLD
VEDDADFGRL VKGRIEKTLL GEISEYIEEV FLPDDCFILV KLSLERIRLL RLEVNAETVR
YSICMSKLRV KPGDIAVHGE AVVCVSPREN SKSSMYYVLQ TLKEDLPKVV VQGIPEVSRA
VIHIDEQTGK NKYKLLVEGD NMRAVMATHG VNGSRTTSNN TYEVEKTLGI EAARSTIINE
IQYTMVNHGM SIDRRHVMLL ADLMSYKGEI LGITRFGLAK MKESVLMLAS FEKTADHLFD
AAYFGQKDSV CGVSECIIMG IPMNIGTGLF KLLHKADKDP SPVKRPLLFD SPDFHVPLIR
//
