ID   A0A3Q3FRI0_9LABR        Unreviewed;       540 AA.
AC   A0A3Q3FRI0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Caspase-8-like {ECO:0000313|Ensembl:ENSLBEP00000022442.1};
OS   Labrus bergylta (ballan wrasse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Labriformes; Labridae; Labrus.
OX   NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000022442.1, ECO:0000313|Proteomes:UP000261660};
RN   [1] {ECO:0000313|Ensembl:ENSLBEP00000022442.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C14A family.
CC       {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR   AlphaFoldDB; A0A3Q3FRI0; -.
DR   STRING; 56723.ENSLBEP00000022442; -.
DR   Ensembl; ENSLBET00000023622.1; ENSLBEP00000022442.1; ENSLBEG00000017240.1.
DR   GeneTree; ENSGT00940000160994; -.
DR   InParanoid; A0A3Q3FRI0; -.
DR   OrthoDB; 2873736at2759; -.
DR   Proteomes; UP000261660; Unplaced.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd00032; CASc; 1.
DR   CDD; cd08792; DED_Caspase_8_10_r1; 1.
DR   CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR033139; Caspase_cys_AS.
DR   InterPro; IPR016129; Caspase_his_AS.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   InterPro; IPR002138; Pept_C14_p10.
DR   InterPro; IPR001309; Pept_C14_p20.
DR   InterPro; IPR015917; Pept_C14A.
DR   PANTHER; PTHR48169:SF5; CASPASE 10; 1.
DR   PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01335; DED; 2.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   PRINTS; PR00376; IL1BCENZYME.
DR   SMART; SM00115; CASc; 1.
DR   SMART; SM00031; DED; 2.
DR   SUPFAM; SSF52129; Caspase-like; 1.
DR   SUPFAM; SSF47986; DEATH domain; 2.
DR   PROSITE; PS01122; CASPASE_CYS; 1.
DR   PROSITE; PS01121; CASPASE_HIS; 1.
DR   PROSITE; PS50207; CASPASE_P10; 1.
DR   PROSITE; PS50208; CASPASE_P20; 1.
DR   PROSITE; PS50168; DED; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   DOMAIN          2..79
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          90..156
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   DOMAIN          297..423
FT                   /note="Caspase family p20"
FT                   /evidence="ECO:0000259|PROSITE:PS50208"
FT   DOMAIN          434..521
FT                   /note="Caspase family p10"
FT                   /evidence="ECO:0000259|PROSITE:PS50207"
FT   REGION          176..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          244..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        244..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  60552 MW;  05EB786751714A90 CRC64;
     MDFQKLQLDV GKALSQEEVK ALAFLCTDLL GLKVTSVGSA SDLFSRMVEQ DLLSAEKPHL
     LTELLLIIQR TRLIRDLRLT ESTTKNLISS YRKLLYNLSE DITDANLKDI KFLLKGQLSR
     RQLEDNVTTL EVFLEMEHKD LINDTNLNLL EKLLQTCCPV LTEEINRYKE QQASLHSSHI
     AQETGRPRSI SCPPEPNQNQ CLPFSHPERC RSTDFSDPPP LPESTMSPSN TSVDEYLSLS
     LSRLSTTRSS SPSSNVGSDA SVISPSQLNE NSSQQQTAQT TNTNTEDLGS YPMTAAKRGL
     CLIINNNNFS ESKQRLQMRE GTMVDEERLT KVFEWLAFHV VIERDCDRKK MLCLVQNLGK
     EDHHDVDCLV CCVLSHGEQD GVYGVDGLTV TLNELKEPFN GSKCPSLTEK PKLFFIQACQ
     GVSRQEPVYI ESDGHDSIPS EADFLLAMAT VPSYVSFRER SNGTWFIQAL CQNLIQMVPK
     GLDLMSILTK VNADVSRKTD NTGQKKQMPQ PAFTLRKKVV FPIPKAPPPS LKSLINSHNK
//