ID A0A3Q3FRZ6_9LABR Unreviewed; 997 AA.
AC A0A3Q3FRZ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Gamma-aminobutyric acid type B receptor subunit 1-like {ECO:0000313|Ensembl:ENSLBEP00000022239.1};
GN Name=GABBR1 {ECO:0000313|Ensembl:ENSLBEP00000022239.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000022239.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000022239.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000256|ARBA:ARBA00008991}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR STRING; 56723.ENSLBEP00000022239; -.
DR Ensembl; ENSLBET00000023415.1; ENSLBEP00000022239.1; ENSLBEG00000017055.1.
DR Ensembl; ENSLBET00000023446.1; ENSLBEP00000022268.1; ENSLBEG00000017055.1.
DR GeneTree; ENSGT00940000157642; -.
DR OrthoDB; 2970339at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15291; 7tmC_GABA-B-R1; 1.
DR CDD; cd00033; CCP; 2.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR002456; GPCR_3_GABA_rcpt_B1.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF76; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00084; Sushi; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SMART; SM00032; CCP; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..997
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041078474"
FT TRANSMEM 589..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..686
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 767..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..157
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 596..875
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 865..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..960
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 128..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 997 AA; 112273 MW; 26462CEC4007D15B CRC64;
MARLLFLIVL YALPSPVVPI HNSSTGGCAI IRPPRDGGIR YRGLTQEQIR SVQILPVDYE
IEYICRGNRV IVGPKVRKCL PDGTWTDITL HSRCLLLCPR VWTSLENGRV SVKPPGPPVE
GTVLHYSCHA GFILEGRNIS HCTKLGKWDA PKPTCLYDRN YTGKKKLYIG ALFPMSGGWP
GGQACMPSAQ MALDLVNNRS DILPDYELEL IHYDSMCDPG ESTKLLYDLL YTEPIKIVLM
PGCSGVSTIV AEAARMWNLI VLSYGSSSPA LSNRQRFPTF FRTHPSATLH NPTRVQLFQK
WKWTRIATIQ QTTEVFTSTL DDLEQRTKEA GIEISVRQSF LTDPAVAVKN LKRQDARIIV
GLFYETEARK VFCEVFKEKL YGKKYVWFLI GWYADNWFKI KDPAINCTIE NMTEAVEGHV
TTEIVMLNPE TVRGVSNMTS QEFIAALMSR LGGMNPEETG GFQEAPLAYD AVWALALALN
KTVAPLKAKG RRLEDFNYNN HDITSEIYRA LNTSSFEGVS GQVVFDAQGS RMAMTLIEQL
QGGSYKKIGY YDSSQKNLSW FDNDVWIGAG PPADRTVVII EYRFLSQKLF AAVSVFAGLG
ILLGIVCLTF NIYNGNVRYI QNSQPYLNNM TAVGCMMALA AVFPLGIDGH HVLRSQFPVV
CQFRLWLLGL GFSLAYGSMF TKIWWVHTLF TKKEEKKEKK KQHLEPWKLY ATVGVLLAID
FLSLMIWQIV DPLHVTDEKF TKEAPKEDKD VLIQPLLEHC SSEKMNTWLG VVYGYKGLLL
LLGIFLAYET KSVSTEKIND HRAVGMAIYN VAVLCLITAP VTMILTSQQD ASFAFASLAI
VFSAYITLVV LFVPKMRRLI TRGEWQSEQQ DTLKTGSSTN NNDEEKSRQL ERENRELQKI
IQEKEERVSA LRNQLAERQA LRNRRRPSSG QNQNHNTPPP SSQPDPKSLL PPPGYPNPTT
DNHSLPPSFS NSSNLYPADS KMSRNHCHNS QIPLLYK
//
