ID A0A3Q3FSQ8_9LABR Unreviewed; 1390 AA.
AC A0A3Q3FSQ8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000022504.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000022504.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR Ensembl; ENSLBET00000023685.1; ENSLBEP00000022504.1; ENSLBEG00000017168.1.
DR GeneTree; ENSGT00550000074891; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR CDD; cd05532; POLBc_alpha; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 1.10.3200.20; DNA Polymerase alpha, zinc finger; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR024647; DNA_pol_a_cat_su_N.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR038256; Pol_alpha_znc_sf.
DR InterPro; IPR045846; POLBc_alpha.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015088; Znf_DNA-dir_DNA_pol_B_alpha.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF12254; DNA_pol_alpha_N; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF08996; zf-DNA_Pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF90234; Zinc finger domain of DNA polymerase-alpha; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 33..94
FT /note="DNA polymerase alpha catalytic subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12254"
FT DOMAIN 396..692
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 757..1205
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 1245..1363
FT /note="Zinc finger DNA-directed DNA polymerase family B
FT alpha"
FT /evidence="ECO:0000259|Pfam:PF08996"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1390 AA; 157326 MW; 369C02A41144E41E CRC64;
MSSRHDDGGD ACGLAKSRSR REKREKVGRK SALEQLKKAK MGEKIKYEVE EFTSVYEEVD
EQQYSKMVRE RQEDDWIIDD DGTGYVEDGR EIFDDDLHDD VVENKKGKPG AKGADSKKNV
KKSAVAKPNT IKSLFNNSNV KRPVEKDVDL SKDDLLGDIL QDLHSEKPSL LTPPPVVTLK
KKKSLGTPLN PFSIKPQTPK VFLKSVKEKN QDTNVTFLFC FLSSSKLTIM TTRFSVNDAM
AFDGVDFDEP MEVGLEEQKP EIKDAAESDP KAAAAVVAVK TESGRISTWG QEEEEGVASD
APAEVQVDSS RLPLAEGPDG EQVFRFYWLD AFEEPYSQPG VVYLFGKVWI ESAKSHVSCC
VSVKNIERTM YFLPREYKVN TKTGEVSGTP VGMMDVYQEF NELSEKFKIM KFKSKKVERS
YAFEIPDVPS QCEYLEVRYS AEFPALPSDL KGATFSHIFG NNTSSLEHFL LSRKIKGPCW
LDIKTPQLIS QPVSWCKVEA LALRSDLVTV VKDLPPPPIT VMSISLKTIQ NPKTHHNEIV
SLAALIHYNF HMDKAAPQPP YQTHFCVVSR PADCIFPYDF KEAVRKKNGK VEIASTERTL
LGFFLAKMHK IDPDVLVGHD IFGFDLEVIL QRINFCKVPH WSKMGRLRRA TMPKLGGRGS
FAEKSATCGR LVCDVEISAK ELIRCKSYHL TELTAQVLKT ERVALPQENI KNLYSDSPHL
LYLLEMTWTD AKLILQIMCE LNVLPLALQI TNIAGNVMSR TLMGGRSERN EFLLLHAFHD
KNFIVPDKPS FKKAQLEVDG EDDADTGKGK RRKKAAYAGG LVLDPKVGFY DKFVLLLDFN
SLYPSIIQEF NICFTTVQRE AYNAQKKNQE DESEEIPEIP DSDLEMGILP KEIRKLVERR
KQVKQLMKQQ DINPDLYLQY DIRQKALKLT ANSMYGCLGF SYSRFYAKPL AALVTHKGRE
ILMHTKDLVQ KMNLEVIYGD TDSIMINTNS RSLEEVFKLG NKVKAEVNKL YKLLEIDIDG
VFKSLLLLKK KKYAALVVEN HGEGRYSVKQ ELKGLDIVRR DWCDLAKECG NYVIGQILSD
QSRDAIVENI QKHLVEVGEK VAAGAIPLNQ YEIHKALTKD PQDYPDKKSL PHVHVALWIN
SQGGHRVKAG DTVSYIICKD GSTLAASQRA YALEQLQKQE NLSLDTQYYL AQQVHPVVSR
ICDPIDGIDG VLIATWLGLD PSQFRAHQQY QREDEADGTL GAPVQLTDEE RYKDCERFTF
TCPQCGTDNT YDSVFEGAGS KMEPSLLQCC HIPCGSRPVD YVVNISNKLL LDIRRHIKKY
YSGWLVCEDQ ACQNRIRRLP IAFSRHGPIC PACTRATLRP EVTRTIHTLT HTHTHHHTSF
HTLEWEEQNA
//
