ID A0A3Q3FTB5_9LABR Unreviewed; 1167 AA.
AC A0A3Q3FTB5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nidogen-1-like {ECO:0000313|Ensembl:ENSLBEP00000022183.1};
GN Name=NID1 {ECO:0000313|Ensembl:ENSLBEP00000022183.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000022183.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000022183.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q3FTB5; -.
DR Ensembl; ENSLBET00000023358.1; ENSLBEP00000022183.1; ENSLBEG00000016844.1.
DR GeneTree; ENSGT00940000156318; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00053; EGF; 2.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR46513:SF6; NIDOGEN-1; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 5.
DR SMART; SM00539; NIDO; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..234
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 325..365
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 369..602
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 597..638
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 639..681
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 691..734
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 735..771
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 781..862
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 911..953
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 954..996
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 997..1041
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1122..1163
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 259..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 129785 MW; 5FA9141C5962980F CRC64;
SLRYQDSFFF FFKQTNHIFI LIFSFLFLTF SLHGHGSLLI NTNGFVSMVD PPAEEEYLGK
MPASFKMMAA LLGDLDNSDG QGRVYYRTDI SPDVLNQAAE HIRQAFPRDN GVDPSSTFIV
TWENMAARGT SGRGDGLDAK RNTFQLVVVS MESSSCTILL YPRHHLQFLS TSVGGESKLL
EAGFNEGLVT GWFWKTKQGD YFQITTEEES SIRDLTEKTT SGQFGVWVYE IGSSPIFLSI
TPGMVSGPPE DEDAIPPAGT ELPRQHAGDY STYRPENRPR YPELEIGYPD HRYTPVQPRY
PDPVPPQIVV VDEDEDLNVN VFAYNLETCA HNRHKCSAFA DCRDYSNGYC CHCRPGFYGN
GKDCVAEGKP QRMNGKVNGR VFVGNSALPI ELNNNDLHSY VVANDGRAYV AISNIPKSLG
PSLQLLSSLG GVIGWAFALE QPGYQNGFSL VGGVFTRQAE VIFYPGNERL NIKQQFKGID
EHDHLVVSTE LEGRLPAIPL GSSVQINPYK EIYQYDRNLI TSSSNRDYTI SSPDGSSQTS
SYQWRQTVTF ESCQHDEATR EVPSTQQLSV DQIFVMFDTE NDLIRYAMSN KIGSLPEQNP
CFTGRHGCDI NAVCRPGEGL QFTCECTTGF TGDGRYCHDT DECRETYNIC GNNAVCTNQP
GTFRCECLTG FVFASDGRTC IGNVYVHHSG PVDHCRRGSH DCDDPQRAQC SYTGGSAYIC
SCLPGFVGDG RVCRDVDECE HDRCHRDAAC SNTEGSFSCQ CHPGYHGDGF QCSPTSTERE
KTQCERHRES VQAATSSSGI FSFFRPRPAV GQYVPQCDQH GAYEPTQCHT SIQQCCTPLC
IDQAVTPAPV GPTPRPDVHP VAPGTHLLFA QSGRIEHLPL DGYSFKKEDA KPLLHIPDRV
VIAVAYDCVD KMVYWTDITG PAISRARMSG GDISHVITTE LQSPEGIAID HVARLLFWTD
SMRDTVEVSK LDGSQRRVLF DTDLINPRAI VTNPAYGRIF WADWNRDGPK IEMSNMDGTD
RTVLVKDDLG LPNGLTFDIE NQQLCWADAG TRKVECMDPH RQLRRQVVEG IQYPFGLVSF
GKNLYYTDWR REAVVAVDSQ AEKETEEFLP QKRSRLYGIT TTPTQCPQAY NYCSNNGGCS
HLCLPRLGGF TCRCPDGSAG SCEERNL
//
