ID A0A3Q3FVV1_9LABR Unreviewed; 705 AA.
AC A0A3Q3FVV1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=RAS guanyl-releasing protein 1-like {ECO:0000313|Ensembl:ENSLBEP00000023494.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000023494.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000023494.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RASGRP family.
CC {ECO:0000256|ARBA:ARBA00009566}.
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DR AlphaFoldDB; A0A3Q3FVV1; -.
DR STRING; 56723.ENSLBEP00000023494; -.
DR Ensembl; ENSLBET00000024727.1; ENSLBEP00000023494.1; ENSLBEG00000018003.1.
DR GeneTree; ENSGT00940000159883; -.
DR InParanoid; A0A3Q3FVV1; -.
DR OrthoDB; 4260488at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0001945; P:lymph vessel development; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF157; RAS GUANYL-RELEASING PROTEIN 4; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00054; EFh; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 41..162
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 187..418
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 452..487
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 525..575
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 80346 MW; 98A5BE191AB2728A CRC64;
MNKTKRKSNV DSLKKGKLVP RRRNTCPSPQ DITRALQSPS SAPSASAASL DELIQRCLNC
FDSEGKFSSQ LVHMTLMMHS WVVPSQMFAQ KLLTIYKDCP SDKRGLRRSQ VCHLIRQWMS
QFPAVFEADP LLEQTMGDLW ALVRLDGEEK HSQLMDTSCL SPHVNIFQAP SPSVKKRKVS
LIFDHMEPDE MAKHLSYLEF KNFCNVSYLD YRSYVVRGSV RDNPALERSV MMCNGVSQWV
QLMILSRHTA QQRAQVFTKF THVAQKLRAL QNFNTLMAVT GGLCHSSISR LKDTSNLLPP
DVTKALSEMT ELLSSRSNYS NYRRVYSECS GFKVPILGVH LKDLISLNEA LPDYIDADKI
NLSKLQHLYS NITDLLAIHS STPPFEANKD LLHLLTLSLD LYYTEDEIYE LSYTKEPKNP
KIQPVAPVKP PVVAEWGSGV TPRLDPDTIS KHVKQMVDSI MKNYDQNQDG YISHEDFEKI
AANFPFSFCT HETDREGQIS REEINSYFMR GMSVWAKLGY NFSDVHNFHE TTYKRPTFCY
ICGGFLWGVI KQGYHCKDCG INCHRHCRDL VGMECSKKHK NSTGSCPCTP APESRSKGGV
WSSEEEAFVF PQSIDTHHNK GLSVWTNSTS DSTLSDRSTQ TDPGVWTPEK REMRGNHHNS
LVHASPERRV NTLPLRTRGC SMPVSFLQEK MEELHFYKDK SREPD
//
