ID A0A3Q3FWI8_KRYMA Unreviewed; 1070 AA.
AC A0A3Q3FWI8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=DAB2 interacting protein {ECO:0000313|Ensembl:ENSKMAP00000016722.1};
OS Kryptolebias marmoratus (Mangrove killifish) (Rivulus marmoratus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; Kryptolebias.
OX NCBI_TaxID=37003 {ECO:0000313|Ensembl:ENSKMAP00000016722.1, ECO:0000313|Proteomes:UP000264800};
RN [1] {ECO:0000313|Ensembl:ENSKMAP00000016722.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017286738.1; XM_017431249.1.
DR AlphaFoldDB; A0A3Q3FWI8; -.
DR Ensembl; ENSKMAT00000016956.1; ENSKMAP00000016722.1; ENSKMAG00000012390.1.
DR GeneID; 108244777; -.
DR GeneTree; ENSGT00940000155853; -.
DR OMA; RTRPARX; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000264800; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000264800}.
FT DOMAIN 1..89
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 80..198
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 258..450
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 542..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 909..982
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1012..1039
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 611..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 119353 MW; 05075C54BA07E83F CRC64;
MFHIFSRSSQ LMPRLKESRS HESLLSPSSA VEALDLSMED EVIIKTVHSS ILGQDYCFEV
TTSTGSKCFS CRSAAERDKW MENLRRAVQP NKDNSRRVEN LLRLWLIEAK DLPAKKKYFC
ELCLDDSLYA RTTCKLKTDN VFWGEHFEFS NLPAVKSITA HLYKDTDKKK KKDKNNYIGL
VTIPVAAVTG RQFVEKWYPV STPNPPKGKT SGPMIRIKAR YQSMSILPME MYKEFAEYTT
NNYMLLCSVL EPGISVKNKE EMACALVHIL QSTGKAKDFL TDLMMSEVDR CGENEHLIFR
ENTLATKAIE EYLKLVGQKY LQDALGEFIK ALYESDENCE VDPSKCSSGD LPEHQSNLKM
CCELAFCKII NSYCVFPREL KEVFASWRQE CSNRGRPDIS ERLISASLFL RFLCPAIMSP
SLFNLMQEYP DDRTARTLTL IAKVTQNLAN FTKFGNKEEY MSFMNQFVEH EWTNMQRFLL
EISNPETISN TAGFEGYIDL GRELSTLHSL LSEVVSQTDQ NAASKLGPLP RILREVNTAL
SNPSSVHMTP GPSSEPAHSP PAEAGSSISS GLQKMVIDSE LSGLVDFTRL PSPTPENKDL
FFVTRSSAIQ SSPARSSSYS ETNEPDLSMT NGSKSLSMVD LQDPHTLDSG TGPSLSDALG
EGQASGGGWS ARVSQGNIPA GPTPRRPGQT PTTPGTESTP GRPPQLLAPL SFQNPVYQMA
ACLPVSPRGM TDSGSECHSS VSSHSNNEDG PAAGKQAFMN HGGGSSGDEY TRRSGDFNRR
QLSLTETPHQ PTVPRQNSAG PQRRIDQPPP QSITRGRTPP NLLSSGPFPR PPSGNMMTSS
PDWPAGGTRL RQQSSSSNID SPESKQRAQH KQAPSPVNPS ALDRTAAWLL NMNVQFLDHE
GMEPESLRHT DHQTEVEKYQ QEIAVLQEKL RASVQKLEEY EARLKGQDEQ AQKVLMEYQA
RLEESEERLR RQQDDKDLQM KSIISRLMSV EEELKKDHSD MQAVVDSKQK IIDAQEKRIA
SLDAANARLM SALSQLKERY SIQTRNGISP TNPSKLQITE NGEFRNSSNC
//
