ID A0A3Q3FXA0_9LABR Unreviewed; 887 AA.
AC A0A3Q3FXA0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Eosinophil peroxidase-like {ECO:0000313|Ensembl:ENSLBEP00000024822.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000024822.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000024822.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A3Q3FXA0; -.
DR STRING; 56723.ENSLBEP00000024822; -.
DR Ensembl; ENSLBET00000026086.1; ENSLBEP00000024822.1; ENSLBEG00000018966.1.
DR GeneTree; ENSGT00940000166204; -.
DR InParanoid; A0A3Q3FXA0; -.
DR OrthoDB; 4560at2759; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IEA:UniProt.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR11475:SF63; EOSINOPHIL PEROXIDASE; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00084; Sushi; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS50923; SUSHI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..887
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018540335"
FT TRANSMEM 843..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 755..809
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT BINDING 508
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 887 AA; 98919 MW; 362A3F2A0B6119D2 CRC64;
MDRAPMVSVC LLGLALILLS FSEHASMDAV SQNNSGVSET VYPGSVFVKE ALQRAIKLTD
AAYARTSERV KKSLSEGALR PNDLLAQFKQ TEARTRTQIW AAELLDNTVE LIREMVYTHT
MTIPSPHELL SEGDVENLLQ ATGCSTELQR PSCDTDCLSN RYRSLTGECN NRRHPRWGAA
NIPYSRWLPP EYEDEWGMPR GWDPEHTYHN TTLPPVRLVS QEVLFTHNDN ISLDSTLSHL
LVEWGQWIDH DIVLTPQSPS TASFRNGADC TRTCSRDTPC FPIQIPLSDP RYGIQSCMPF
FRSAPSCVSG ILSHRQREQL NAITSFVDAS MVYGSSTSLA SALRNNSSPL GMMAHNSQHL
DQELAYMPFL PRLQAHLDPC GPRNSTTSGE WDRSTHQKNT TSCFHAGDSR ANEHLGMIAL
HTLFLREHNR LVKELHLLNP HWSPDTLYQE ARKILGAIHQ ILTWNHYLPL VLGEITMPHL
MPPYEGYNPE VDPSIANAFA AAAFRFAHVT VHPVVNRLGP GYTTDSQHAP LPLHHSLFAS
WRVIQEGGID PVLRGLLLSP AKLQTPGQMM VEELTERLFQ AQGGMPLDLG ALNLQRGRDH
GLPGYCSWRK FCSLSVPNTT SELAEILSNF TLAHKLQLLY GTPHNIDVWV GAISEPALPG
GRVGPLLSCL LARQFRALRD GDRFWWEREG LFTSTQRRHL HSVSLSRIIC DNSHITHVPA
DPFSRTERPE DMLACSHPLI SKLDISPWKE PDTDPSCGPI PRIQSGYSLL CDSAILYQCR
AGFKLLGSSS VKCDLNSQQW SPKPPTCEDI NECEEQSSLC QQNLECLNTP GSFICSEPFS
QSAVSVVTAV IVVIGGVAVL LLIMFCYRRY FPKKEELINA ACCQGQS
//
