ID A0A3Q3FYM9_9LABR Unreviewed; 2277 AA.
AC A0A3Q3FYM9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN Name=SPTBN1 {ECO:0000313|Ensembl:ENSLBEP00000024504.1};
OS Labrus bergylta (ballan wrasse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Labriformes; Labridae; Labrus.
OX NCBI_TaxID=56723 {ECO:0000313|Ensembl:ENSLBEP00000024504.1, ECO:0000313|Proteomes:UP000261660};
RN [1] {ECO:0000313|Ensembl:ENSLBEP00000024504.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSLBET00000025766.1; ENSLBEP00000024504.1; ENSLBEG00000018090.1.
DR GeneTree; ENSGT00940000154864; -.
DR Proteomes; UP000261660; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd00176; SPEC; 9.
DR Gene3D; 1.20.58.60; -; 12.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF226; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 1; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00435; Spectrin; 17.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 17.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 13.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000261660};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 34..138
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 150..238
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 2074..2141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2224..2277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 952..986
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1058..1085
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2076..2104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2111..2127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2224..2253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2254..2270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2277 AA; 262792 MW; 6C5EFBB6D9590F59 CRC64;
MMEAEWAMGD PVHQQQNYNL LEGRFKQLQD EREAVQKKTF TKWINSHLSR VSCRITDLYM
DLRDGRMLIK LLEVLSGERL PKPTKGRMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD
GNHRLTLGLI WTIILRFQIQ DIRFCSVVMY PNVNIHNFST SWRDGMAFNA LIHKHRPDLI
DFDKLKKSNA HYNLQNAFNL AEQHLGLTKL LDPEDISVDH PDEKSVITYV VTYYHYFSKM
KALKVEGKRI GKVLDNAIET EKMVEKYESL ASDLLEWIEQ TIIILNNRKF ANSLLGVQQQ
LQAFNTYRTV EKPPKFTEKG NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE
KAEHERELAL RTELIRQEKL EQLARRFDRK AAMRETWLSE NQRLVSQDNF GFDLQAVEAA
TKKHEAIETD ITAYEERVQA VVSVARELEV EHYHDIKRVT ARKDNVIRLW EYLLELLKAR
RQRLEMNLGL QRVFQEMLYI MDWMDEMKML LLSQDYGKHL LGVEDLLQKH ALVEADIAIQ
ADRVKAVSTN ANKYSVNDDG YKPCDPMVIQ DRVSHLEFCY QELTQLAAER RARLEESRRL
WKFFWEMAEE EGWIREKEQI LSSVEHGKDL TGALRLLSQQ RALEDEMSGR AGHLQHSVAE
GEAMVEAGHF AAAKIQDRIA DLKAQWAGLE QLAAVRKTRL EEALALHQFQ ADADDVDAWT
LDALRIVSSG ETGHDEFSTQ ALVRKHKDAA AEVASYRPVI DSLHEQAAAL PKEEAESEEV
RGRLAGIEER YREVSELTKL RKQALQDALA LYKMFSEANA CEVWIDEKEQ WLNSMEIPEK
LEDLEVVQHR YDTPLEPEMN NQASRVAVVN QIARQLMHNG HPSEREIKSQ QDKLNNRWSQ
FRDLVDLKKE SLNSALGVQN YHLDCNETKS WIKEKTKVIE STQELGNDLT GVMALQRKLT
GMERDLAAIE DKLGDLRGEA ERLAQEHPDQ AKAITGRLSE ITAVWEEMKN TLKNREDSLG
EARKLQQFLR ELDDFQSWLS RTQTAIASED MPNTLAEAEK LMAQHEGIKN EIQNYEEDYQ
KMRDMGEMVT QGQTDAQYMF LRQRLQALDT GWNELHKMWE NRQNLLSQSH AYQLFLRDTK
QAEAFLNNQE YVLAHTEMPT TLEAAEAAIK KQEDFMTTMD ANEDKINGVV EAGRRLASDG
NINAEKIQER VASIDDRHKK NREAAVELLM RLKDNRDLQK FLQDCQELSL WINEKMLTAQ
DMTYDEARNL HSKWLKHQAF MAELQSNKEW LDKIQKDGTL LVSEKPETDA VVKEKLSALH
AMWAELESTT QTKAQCLFDA NKAELFTQSC ADLDKWMGGL EGQIQSDDYG KDLTSVNILL
KKQQMLEKQV EVRQRGVELQ SQVKALGQEV KDTEEVDGRR QLVENKFQEL LDPLRRRRNF
LVASREVHQF NRDLEDEILW VQERMPVATS TDHGNNLQTV QLLIKKNQTL QKEIQGHQPR
INDLLEHSAS LLQDESLSGE VIRQRLADLQ ELWRREAHKA QQYYFDAAEA EAWMSEQELY
MMSEEKAKDE LSAVTMQKKH QIVEQAVEDY AETSTCCPRP AERISMRQSQ VDKLYAGLKD
LSEERRGKLD ERLRLFQLNR EVDDLEQWIA EREVVAGSHE LGQDYEHVTM LQERFREFAR
DTGNIGQERV DAVNRLADEL INTGHGDAAT VAEWKDGLNE AWADLLELID TRTQILAASF
ELHKFYHDAK EILGRIVDKQ KKLPEEVGRD QNTVDTLQRM HTTFEHDIQA LGTQVRQLQE
DAVRLQSAYA GDKADDIQRR ESEVLEAWRI LLEACEGRRL RLLDTGDKFR FFSMVRDLML
WMEDVIRLIE AQENPRDVSS VELLMNNHQG IKAEIDARND SFTACIELGK ALLARKHYAS
EEIKEKLLQL TDKRKDMIDK WEDRWEWLRL ILEVHQFSRD AGVAEAWLLG QEPYLSGRDM
GQSVDEVEKL IKRHEAFEKS AATWEERFSA LERLTTVRGS RRRRSFLRKP PTPELLPVQE
SFKIHHVRLE QMSLCIPPSQ DGMVDGELVN GVVERSSKEP SPSGSPTSGR KSKTSQSSTL
PPGTRSPRPR WRASCTANTS GRGTTRRPPT GNKDPLLQEG ETSHSACTAL ITLSPPSLIG
RSWHNVYCVI NNQEMGFYKD SKAASQGVPY HNEVPVGLKE ATCSGFREEM STWIQAILNA
GADRSSVQGS HPGTPVSGRA QTLPATVTLT TESSPGKREK DKEKEKEKRF SLFKKKQ
//
